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dc.contributor.authorKarsli, B
dc.contributor.authorKaya, T
dc.contributor.authorCetin, A
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:25:41Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:25:41Z
dc.date.issued1999
dc.identifier.issn1230-6002
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11732
dc.descriptionWOS: 000084773200007en_US
dc.descriptionPubMed ID: 10817528en_US
dc.description.abstractEmergent or elective surgical procedures under general anesthesia may be required during pregnancy for some patients. For this reason, effects of anesthetics on uterine contractions are important. General anesthesia is not limited to the administration of inhalation agents, since induction and maintenance of anesthesia usually involve intravenous administration of different anesthetic agents. The effects of these agents on uterine contractions and blood flow are very important. The unexpected relaxation or contraction of myometrium can be harmful to fetus and continuing pregnancy. Our aim in this study is to investigate the effects of intravenous anesthetic agents on uterine contractions. In our study, we examined the effects of ketamine, propofol and midazolam on contractions of isolated pregnant rat myometrium. We observed that exposure to propofol, ketamine and midazolam at the concentrations of 10(-5)-10(-4) M decreased spontaneous contractile activity in myometrial strips isolated from pregnant rats. There was statistically significant difference between the control and all strips exposed to propofol, ketamine and midazolam in the contraction amplitude and integrated area under the contraction curve.en_US
dc.language.isoengen_US
dc.publisherPOLISH ACAD SCIENCES INST PHARMACOLOGYen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectketamineen_US
dc.subjectpropofolen_US
dc.subjectmidazolamen_US
dc.subjectmyometriumen_US
dc.titleEffects of intravenous anesthetic agents on pregnant myometriumen_US
dc.typearticleen_US
dc.relation.journalPOLISH JOURNAL OF PHARMACOLOGYen_US
dc.contributor.departmentAkdeniz Univ, Sch Med, Dept Anesthesiol & Reanimatol, Antalya, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894en_US
dc.identifier.volume51en_US
dc.identifier.issue6en_US
dc.identifier.endpage510en_US
dc.identifier.startpage505en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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