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dc.contributor.authorKaya, T
dc.contributor.authorCetin, A
dc.contributor.authorCetin, M
dc.contributor.authorSarioglu, Y
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:25:56Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:25:56Z
dc.date.issued1999
dc.identifier.issn0024-7758
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11764
dc.descriptionWOS: 000079014400009en_US
dc.descriptionPubMed ID: 10853442en_US
dc.description.abstractOBJECTIVE: We studied the effect of endothelin (ET)-1 on spontaneous contractions and the effects of nimodipine and isradipine on ET-l-induced contractions in myometrial tissue from normal and diabetic pregnant women. STUDY DESIGN: We isolated myometrial strips from seven normal pregnant and seven gestational diabetic women undergoing elective cesarean section at term. Three sets of experimental studies were performed with three myometrial strips obtained from every woman and mounted in organ baths for recording of isometric tension. In the first set, the effect of increasing concentrations of ET-I (10(-11)-10(-8) M) On spontaneous contractions was recorded. In the second and third sets, effects of increasing concentration of nimodipine (10(-6)-3.10(-5) M) and isradipine (10(-5)-3.10(-4) M), respectively, on contractions following pretreatment with 10(-8) M ET-1 were recorded. RESULTS: ET-ir, beginning from 10(-9) M and 10(-10) M, significantly increased the amplitude of contractions in normal and diabetic strips, respectively. ET-I, beginning from 10(-9) M, also increased the frequency of contractions in normal and diabetic strips. The amplitude of contractions was significantly higher in diabetic strips as compared with normal strips at 10(-9) and 10(-8) M. There was no significant difference in the frequency of contractions between normal and diabetic strips. ET-I at 10(-8) M also increased the basal tone of all normal and diabetic strips. Nimodipine, beginning from 10(-6) M and 3.10(-6) M and ismdipine, beginning from 10(-5) M and 3.10(-4) M, significantly decreased the amplitude of contractions in normal and diaetic strips, respectively. Nimodipine at 10(-5) M and 3.10(-5) M and isradipine at 3.10(-4) M significantly decreased the frequency of contractions in normal strips. Nimodipine, except at 3.10(-5) M, and isradipine did not significantly decrease thefreqtrency of contractions in diabetic strips. CONCLUSION: Gestational diabetes increases ET-1-induced contractile response in human myometrium. The contractile effect of ET-1 in normal and diabetic myometrium is mediated partly by dihydropyridine-sensitive calcium channels since it is significantly reduced by nimodipine and isradipine. The promising data from this study warrant clinical studies on the definitive place of nimodipine and isradipine in the treatment of preterm labor, especially in a diabetic woman, to avoid metabolic complications of beta-mimetic tocolytics.en_US
dc.language.isoengen_US
dc.publisherSCI PRINTERS & PUBL INCen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcalcium channel blockersen_US
dc.subjectmyometriumen_US
dc.subjectdiabetesen_US
dc.subjectgestationalen_US
dc.subjectpregnancyen_US
dc.subjectendothelin-1en_US
dc.titleEffects of endothelin-1 and calcium channel blockers on contractions in human myometrium - A study on myometrial strips from normal and diabetic pregnant womenen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF REPRODUCTIVE MEDICINEen_US
dc.contributor.departmentCumhuriyet Univ, Sch Med, Dept Pharmacol, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894; SARIOGLU, YUSUF -- 0000-0002-9227-365Xen_US
dc.identifier.volume44en_US
dc.identifier.issue2en_US
dc.identifier.endpage121en_US
dc.identifier.startpage115en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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