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dc.contributor.authorAyan, S
dc.contributor.authorYildirim, S
dc.contributor.authorUcar, C
dc.contributor.authorSarioglu, Y
dc.contributor.authorGultekin, Y
dc.contributor.authorButuner, C
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:25:57Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:25:57Z
dc.date.issued1999
dc.identifier.issn1464-4096
dc.identifier.urihttps://dx.doi.org/10.1046/j.1464-410X.1999.00892.x
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11766
dc.descriptionWOS: 000079775000019en_US
dc.descriptionPubMed ID: 10233462en_US
dc.description.abstractObjective To investigate the changes in corporal reactivity to adenosine and prostaglandin E-1 (PGE(1)) in corpus cavernosal strips from alloxan-induced diabetic rabbits and to determine the effects of insulin therapy. Materials and methods Twenty-four New Zealand white rabbits were studied in three equal groups: group 1, control: group 2, diabetes induced by the administration of alloxan hydrochloride intravenously; group 3, as group 2 but with insulin administered after the induction of diabetes. At the end of 8 weeks, the reactivity of corpus cavernosal strips from the animals was assessed in organ chambers. Results The relaxation responses of corpus cavernosal strips to adenosine were similar in all groups, but the response to PGE(1) was impaired in groups 2 and 3 compared with that in controls. Conclusion If vasoactive drugs am to be used for the diagnosis or treatment of diabetic erectile impotence, direct-acting vasodilators, e.g. adenosine, must be used. In alloxan-induced diabetes, the corporal reactivity to PGE(1) was impaired and insulin therapy did not restore the relaxation responses.en_US
dc.language.isoengen_US
dc.publisherBLACKWELL SCIENCE LTDen_US
dc.relation.isversionof10.1046/j.1464-410X.1999.00892.xen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcorpus cavernosumen_US
dc.subjectdiabetes mellitusen_US
dc.subjecterectile dysfunctionen_US
dc.subjectadenosineen_US
dc.subjectprostaglandin E-1en_US
dc.titleCorporal reactivity to adenosine and prostaglandin E-1 in alloxan-induced diabetic rabbit corpus cavernosum, and the effect of insulin therapyen_US
dc.typearticleen_US
dc.relation.journalBJU INTERNATIONALen_US
dc.contributor.departmentCumhuriyet Univ, Sch Med, Dept Urol, Sivas, Turkey -- Cumhuriyet Univ, Tip Fak, Farmakoloji Anabilim Dali, Dept Pharmacol,Sch Med, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDSARIOGLU, YUSUF -- 0000-0002-9227-365Xen_US
dc.identifier.volume83en_US
dc.identifier.issue1en_US
dc.identifier.endpage112en_US
dc.identifier.startpage108en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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