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dc.contributor.authorDurmaz, R
dc.contributor.authorAydin, A
dc.contributor.authorKoroglu, M
dc.contributor.authorAker, H
dc.contributor.authorOzercan, IH
dc.contributor.authorAtik, E
dc.contributor.authorArici, S
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:26:06Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:26:06Z
dc.date.issued1998
dc.identifier.issn0001-723X
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11786
dc.descriptionWOS: 000079531900004en_US
dc.descriptionPubMed ID: 10358743en_US
dc.description.abstractIn order to determine the positivity rare and genotype of Epstein-Barr virus (EBV) in cases with Hodgkin's disease (HD) in Turkey, 40 tissue specimens from HD patients were analysed. Ten non-lymphoid tissue samples from individuals without any evidence for lymphoma were used as controls. The cases with HD included 33 males and 7 females with a mean age of 28 years. Nodular sclerosis was the most prevalent histological subtype (16/40) followed by mixed cellularity (10/40), lymphocyte predominance (9/40), and lymphocyte depletion (5/40). After histopathological evaluation, deparafinisation and lysis of the specimens, one-stage polymerase chain reaction (PCR) and two-stage (nested) PCR assays were performed with the primers common for both EBV genotypes and the primers specific for EBV types 1 and 2, respectively. EBV DNA was detected in 22 of 40 (55%) cases with HD and in 1 of 10 (10%) control specimens. The distribution of EBV DNA positivity according to the histological subtypes was as follows: 10 of 16 (62.5%) for nodular sclerosis, 3 of 5 (60%) for lymphocyte depletion, 5 of 9 (55.6%) for lymphocyte predominance, and 4 of 10 (40%) for mixed cellularity. Although most of the HD patients were males of 15 - 34 years of age, there were no significant differences between EBV positivities obtained From different sex and age groups. The rates of EBV genotypes were 82% for type 1, 9% for type 2, and 9% for both types, respectively.en_US
dc.language.isoengen_US
dc.publisherSLOVAK ACADEMIC PRESS LTDen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpstein-Barr virusen_US
dc.subjectvirus genotypeen_US
dc.subjectHodgkin's diseaseen_US
dc.subjectpolymerase chain reactionen_US
dc.titleDetection and genotyping of Epstein-Barr virus by polymerase chain reaction in tissues obtained from cases with Hodgkin's disease in Turkeyen_US
dc.typearticleen_US
dc.relation.journalACTA VIROLOGICAen_US
dc.contributor.departmentInonu Univ, Fac Med, Dept Clin Microbiol, TR-44069 Malatya, Turkey -- Inonu Univ, Fac Med, Dept Pathol, TR-44069 Malatya, Turkey -- Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- Firat Univ, Fac Med, Dept Pathol, Elazig, Turkeyen_US
dc.identifier.volume42en_US
dc.identifier.issue6en_US
dc.identifier.endpage381en_US
dc.identifier.startpage375en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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