Show simple item record

dc.contributor.authorUma, S
dc.contributor.authorYildirim, S
dc.contributor.authorSarioglu, Y
dc.contributor.authorButuner, C
dc.contributor.authorYildirim, K
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:26:07Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:26:07Z
dc.date.issued1998
dc.identifier.issn0105-6263
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11788
dc.descriptionWOS: 000078535500008en_US
dc.descriptionPubMed ID: 9972495en_US
dc.description.abstractThe aim of this study was to investigate whether prolonged exposure to a high concentration of isosorbide dinitrate (ISDN) would result in tolerance being developed against its relaxant activity in strips of corpus cavernosum, pre-contracted by phenylephrine. Under these conditions, relaxation induced by ISDN was found. to be significantly reduced. Strips made tolerant to ISDN remained fully responsive to sodium nitroprusside and papaverine. Electrical field stimulation evoked relaxations which were persistent in the presence of tolerance-inducing conditions. These results indicate that desensitization of guanylate cyclase activity is trot likely to be the operating mechanism for nitrate tolerance. We suggest that tolerance may result from the impairment of biotransformation of ISDN ill rabbit cavernosal smooth muscle.en_US
dc.language.isoengen_US
dc.publisherBLACKWELL SCIENCE LTDen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectisosorbide dinitrateen_US
dc.subjectrabbit corpus cavernosumen_US
dc.subjecttoleranceen_US
dc.titleTolerance to isosorbide dinitrate in isolated strips of rabbit corpus cavernosumen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL JOURNAL OF ANDROLOGYen_US
dc.contributor.departmentCumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Hacettepe Univ, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkeyen_US
dc.contributor.authorIDSARIOGLU, YUSUF -- 0000-0002-9227-365Xen_US
dc.identifier.volume21en_US
dc.identifier.issue6en_US
dc.identifier.endpage369en_US
dc.identifier.startpage364en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record