dc.contributor.author | Cetin, M | |
dc.contributor.author | Kaya, T | |
dc.contributor.author | Cetin, A | |
dc.contributor.author | Sarioglu, Y | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:26:11Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:26:11Z | |
dc.date.issued | 1998 | |
dc.identifier.issn | 0031-7012 | |
dc.identifier.uri | https://dx.doi.org/10.1159/000028251 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11795 | |
dc.description | WOS: 000076351400006 | en_US |
dc.description | PubMed ID: 9742292 | en_US |
dc.description.abstract | Our aim was to investigate the effect of isradipine, a second-generation calcium channel blocker, on spontaneous and oxytocin- and carbachol-stimulated contractions of myometrium isolated from nonpregnant and pregnant rats. Amplitude, frequency, duration and integrated area of spontaneous and oxytocin- and carbachol-stimulated contractions of nonpregnant and pregnant rat myometrium were compared before and after the treatment with isradipine (10(-6) to 10(-4) mol/l). Isradipine inhibited contractions of myometrial strips isolated from nonpregnant and pregnant rats in a concentration-dependent manner, with a significant effect on the amplitude (10(-5) to 10-4 mol/l) and integrated area (3 x 10(-6) to 10(-4) mol/1) of spontaneous and oxytocin- and carbachol-stimulated contractions. Isradipine induced similar concentration-dependent effects on the frequency and duration of spontaneous and carbachol-stimulated contractions at higher concentrations (3 x 10(-5) to 10(-4) mol/1) but had no effect on frequency and duration of oxytocin-stimulated contractions. Isradipine appears to be an effective relaxant in rat myometrium. This effect of isradipine may become therapeutically advantageous in clinical application for preterm labor. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | KARGER | en_US |
dc.relation.isversionof | 10.1159/000028251 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | isradipine | en_US |
dc.subject | contractions | en_US |
dc.subject | myometrium, rat | en_US |
dc.title | Inhibitory effects of isradipine on spontaneous and oxytocin- and carbachol-stimulated contractions of rat myometrium | en_US |
dc.type | article | en_US |
dc.relation.journal | PHARMACOLOGY | en_US |
dc.contributor.department | State Railway Hosp, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkey | en_US |
dc.contributor.authorID | Cetin, Ali -- 0000-0002-5767-7894; SARIOGLU, YUSUF -- 0000-0002-9227-365X | en_US |
dc.identifier.volume | 57 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 278 | en_US |
dc.identifier.startpage | 271 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |