dc.contributor.author | Canturk, NZ | |
dc.contributor.author | Utkan, NZ | |
dc.contributor.author | Canturk, Z | |
dc.contributor.author | Yenisey, C | |
dc.contributor.author | Yildirir, C | |
dc.contributor.author | Dulger, M | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:26:14Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:26:14Z | |
dc.date.issued | 1998 | |
dc.identifier.issn | 0971-5916 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11802 | |
dc.description | WOS: 000076372600004 | en_US |
dc.description | PubMed ID: 9798334 | en_US |
dc.description.abstract | We investigated the effect of 16,16-dimethyl prostaglandin E-2 indomethacin and Ginkgo biloba extract on the survival in two experimental sepsis models in rats due to administration of 1 x 10(7) cfn and 1 x 10(9) cfu Escherichia coli. Animals in each model were then randomly divided (10/group) into four groups, administered saline, indomethacin, G. biloba extract and prostaglandin E-2 respectively. When compared, there was no significant difference in the survival period between the two sepsis models (P>0.05). The best survival rate was observed in the PGE(2)-administered animals in the first major model(P<0.05). Indomethacin appeared not to decrease the mortality rates. There was no significant difference in PGE(2) levels between two sepsis models (P>0.05). Our results suggest that elevated prostaglandin E-2 levels following major trauma are not responsible for the postinjury increased susceptibility to infectious complications. Our observations should also discourage aggressive use of cyclo-oxygenase inhibitors for protection against infectious complications after major trauma. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | INDIAN COUNCIL MEDICAL RES | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | cyclo-oxygenase inhibitors | en_US |
dc.subject | free radical scavenger | en_US |
dc.subject | prostaglandin | en_US |
dc.subject | sepsis | en_US |
dc.title | The effects of prostaglandin E-2 indomethacin & Ginkgo biloba extract on resistance to experimental sepsis | en_US |
dc.type | article | en_US |
dc.relation.journal | INDIAN JOURNAL OF MEDICAL RESEARCH | en_US |
dc.contributor.department | Kocaeli Univ, Fac Med, Dept Surg, Genel Cerrahi Anabilim Dali,Sopali Ciftligi, Derince, Kocaeli, Turkey -- Cumhuriyet Univ, Fac Med, Dept Internal Med, Sivas, Turkey -- Aydin Menderes Univ, Fac Med, Dept Biochem, Aydin, Turkey -- Cumhuriyet Univ, Fac Med, Dept Surg, Sivas, Turkey | en_US |
dc.identifier.volume | 108 | en_US |
dc.identifier.endpage | 92 | en_US |
dc.identifier.startpage | 88 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |