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dc.contributor.authorKaya, T
dc.contributor.authorCetin, A
dc.contributor.authorSarioglu, Y
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:26:18Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:26:18Z
dc.date.issued1998
dc.identifier.issn1043-6618
dc.identifier.urihttps://dx.doi.org/10.1006/phrs.1998.0310
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11810
dc.descriptionWOS: 000074197300010en_US
dc.descriptionPubMed ID: 9642036en_US
dc.description.abstractThe aims of this study were to investigate whether a nitric oxide (NO) system is present in the pregnant rat myometrium and whether it differentially inhibits myometrial contractility during midgestation and delivery at term. Myometrial strips were obtained from eight rats at midgestation (day 16) and eight rats during delivery at term, and mounted in an organ bath for assessment of isometric tension. There were scarce spontaneous contractions with gradually increased amplitude that ceased after short periods at midgestation, whereas the frequency of spontaneous contractions increased and were regular, and the amplitude of contractions became stable and long lasting during delivery. Spontaneous and carbachol-induced contractions were decreased by L-arginine and increased by N-G-nitro-L-arginine methyl ester (L-NAME) at midgestation and delivery, but much higher concentrations of L-arginine and L-NAME were required to obtain this effect at delivery. These results show: (1) that there is basal and carbachol-stimulated production of NO in pregnant rat myometrium; (2) that the L-arginine-NO system inhibits myometrial contractility; (3) that the effect of the L-arginine-NO system is elevated at midgestation and decreased during delivery; and (4) that the L-arginine-NO system may contribute to uterine quiescence during gestation and the initiation of labour at term. (C) 1998 The Italian Pharmacological Society.en_US
dc.language.isoengen_US
dc.publisherACADEMIC PRESS LTDen_US
dc.relation.isversionof10.1006/phrs.1998.0310en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnitric oxideen_US
dc.subjectL-arginineen_US
dc.subjectL-NAMEen_US
dc.subjectmyometriumen_US
dc.subjectpregnancyen_US
dc.subjectraten_US
dc.titleChanges in the nitric oxide system of rat myometrium during midgestation and delivery at termen_US
dc.typearticleen_US
dc.relation.journalPHARMACOLOGICAL RESEARCHen_US
dc.contributor.departmentCumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Obstet & Gynaecol, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894; SARIOGLU, YUSUF -- 0000-0002-9227-365Xen_US
dc.identifier.volume37en_US
dc.identifier.issue5en_US
dc.identifier.endpage408en_US
dc.identifier.startpage403en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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