dc.contributor.author | Aytekin Akyüz | |
dc.contributor.author | Ayşenur Taş | |
dc.contributor.author | Dürdane Bekar | |
dc.date.accessioned | 23.07.201910:49:13 | |
dc.date.accessioned | 2019-07-23T16:20:15Z | |
dc.date.available | 23.07.201910:49:13 | |
dc.date.available | 2019-07-23T16:20:15Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 1300-056X | |
dc.identifier.uri | http://www.trdizin.gov.tr/publication/paper/detail/TVRNNU9UZzQ= | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/1181 | |
dc.description.abstract | Purpose: The hypothesis that generalized hyperexcitability of the cerebral cortex, more pronounced in the visual area, is a cornerstone in migraine pathophysiology remains unclear. Methods: We stimulated visual cortex using a 90-mm circular coil placed over the occipital scalp in healthy controls and patients with migraine with aura (MA) and without aura (MO) during the interictal period. Twenty-four MA patients, 14 MO patients and 21 healthy controls were studied. Threshold level and prevalence of stimulation-induced phosphene production were compared among MA, MO and HC groups. Results: The difference in proportion of subjects with phosphene generation in MA and control groups (MA 100% versus control 52.4%, p=0.000) and in MO and control (MO 92.8% versus 52.4%, p=0.000) were significant, but there was no significant difference between MA and MO (p=0.056). The difference in threshold levels in MA (MA 48.6%) and controls (98.2%) and in MO (MO 68%) and controls vere significant (p=0.001 andp=0.001 respectively). There vas also a significant difference between MA and MO (p=0.01). Conclusion: Our data strongly suggest that the occipital cortical neurons may be hyperexcitable in migraineurs, at least during the interictal period. | en_US |
dc.description.abstract | Purpose: The hypothesis that generalized hyperexcitability of the cerebral cortex, more pronounced in the visual area, is a cornerstone in migraine pathophysiology remains unclear. Methods: We stimulated visual cortex using a 90-mm circular coil placed over the occipital scalp in healthy controls and patients with migraine with aura (MA) and without aura (MO) during the interictal period. Twenty-four MA patients, 14 MO patients and 21 healthy controls were studied. Threshold level and prevalence of stimulation-induced phosphene production were compared among MA, MO and HC groups. Results: The difference in proportion of subjects with phosphene generation in MA and control groups (MA 100% versus control 52.4%, p=0.000) and in MO and control (MO 92.8% versus 52.4%, p=0.000) were significant, but there was no significant difference between MA and MO (p=0.056). The difference in threshold levels in MA (MA 48.6%) and controls (98.2%) and in MO (MO 68%) and controls vere significant (p=0.001 andp=0.001 respectively). There vas also a significant difference between MA and MO (p=0.01). Conclusion: Our data strongly suggest that the occipital cortical neurons may be hyperexcitable in migraineurs, at least during the interictal period. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Genel ve Dahili Tıp | en_US |
dc.title | Hyperexcitability of occipital cortex in migraine | en_US |
dc.type | other | en_US |
dc.relation.journal | Gazi Medical Journal | en_US |
dc.contributor.department | Sivas Cumhuriyet Üniversitesi | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 193 | en_US |
dc.identifier.startpage | 189 | en_US |
dc.relation.publicationcategory | Diğer | en_US] |