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dc.contributor.authorAytekin Akyüz
dc.contributor.authorAyşenur Taş
dc.contributor.authorDürdane Bekar
dc.date.accessioned23.07.201910:49:13
dc.date.accessioned2019-07-23T16:20:15Z
dc.date.available23.07.201910:49:13
dc.date.available2019-07-23T16:20:15Z
dc.date.issued2001
dc.identifier.issn1300-056X
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TVRNNU9UZzQ=
dc.identifier.urihttps://hdl.handle.net/20.500.12418/1181
dc.description.abstractPurpose: The hypothesis that generalized hyperexcitability of the cerebral cortex, more pronounced in the visual area, is a cornerstone in migraine pathophysiology remains unclear. Methods: We stimulated visual cortex using a 90-mm circular coil placed over the occipital scalp in healthy controls and patients with migraine with aura (MA) and without aura (MO) during the interictal period. Twenty-four MA patients, 14 MO patients and 21 healthy controls were studied. Threshold level and prevalence of stimulation-induced phosphene production were compared among MA, MO and HC groups. Results: The difference in proportion of subjects with phosphene generation in MA and control groups (MA 100% versus control 52.4%, p=0.000) and in MO and control (MO 92.8% versus 52.4%, p=0.000) were significant, but there was no significant difference between MA and MO (p=0.056). The difference in threshold levels in MA (MA 48.6%) and controls (98.2%) and in MO (MO 68%) and controls vere significant (p=0.001 andp=0.001 respectively). There vas also a significant difference between MA and MO (p=0.01). Conclusion: Our data strongly suggest that the occipital cortical neurons may be hyperexcitable in migraineurs, at least during the interictal period.en_US
dc.description.abstractPurpose: The hypothesis that generalized hyperexcitability of the cerebral cortex, more pronounced in the visual area, is a cornerstone in migraine pathophysiology remains unclear. Methods: We stimulated visual cortex using a 90-mm circular coil placed over the occipital scalp in healthy controls and patients with migraine with aura (MA) and without aura (MO) during the interictal period. Twenty-four MA patients, 14 MO patients and 21 healthy controls were studied. Threshold level and prevalence of stimulation-induced phosphene production were compared among MA, MO and HC groups. Results: The difference in proportion of subjects with phosphene generation in MA and control groups (MA 100% versus control 52.4%, p=0.000) and in MO and control (MO 92.8% versus 52.4%, p=0.000) were significant, but there was no significant difference between MA and MO (p=0.056). The difference in threshold levels in MA (MA 48.6%) and controls (98.2%) and in MO (MO 68%) and controls vere significant (p=0.001 andp=0.001 respectively). There vas also a significant difference between MA and MO (p=0.01). Conclusion: Our data strongly suggest that the occipital cortical neurons may be hyperexcitable in migraineurs, at least during the interictal period.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenel ve Dahili Tıpen_US
dc.titleHyperexcitability of occipital cortex in migraineen_US
dc.typeotheren_US
dc.relation.journalGazi Medical Journalen_US
dc.contributor.departmentSivas Cumhuriyet Üniversitesien_US
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.endpage193en_US
dc.identifier.startpage189en_US
dc.relation.publicationcategoryDiğeren_US]


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