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dc.contributor.authorYildirim, MK
dc.contributor.authorYildirim, S
dc.contributor.authorUtkan, T
dc.contributor.authorSarioglu, Y
dc.contributor.authorYalman, Y
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:38:43Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:38:43Z
dc.date.issued1997
dc.identifier.issn0007-1331
dc.identifier.urihttps://dx.doi.org/10.1046/j.1464-410X.1997.00175.x
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11853
dc.descriptionWOS: A1997XE53500026en_US
dc.descriptionPubMed ID: 9202567en_US
dc.description.abstractObjective To investigate the effects of castration and testosterone on the constricting effect of phenylephrine and endothelium-dependent and -independent relaxing effects of different agonists in the corpus cavernosum of male rabbits. Materials and methods Twenty rabbits were castrated and 10 received testosterone replacement for I month after castration: 10 further rabbits underwent a sham operation and acted as controls. One month after operation the rabbits were killed and their penises excised. Strips of corpus cavernosum were used for isometric tension measurements in organ chambers; concentration-response relationships for phenylephrine, carbachol, adenosine and sodium nitroprusside were obtained by adding the reagent cumulatively to the bath. Results The phenylephrine-induced contractions were markedly lower, with no change in the pD(2) values (i.e. the negative logarithm of the concentration for half-maximal response), in cavernosal strips obtained from castrated rabbits than in those from controls. Endothelium-dependent relaxation elicited by carbachol increased in the castrated group but the relaxation induced by sodium nitroprusside did not change and those elicited by adenosine were strongly depressed when compared with controls, There were no significant changes in the pD(2) values of agonist-induced relaxation responses in all groups. The relaxation elicited by electrical-field stimulation at lower frequencies increased in strips from castrated rabbits but at higher frequencies were unchanged when compared with controls. Castration-induced changes in the relaxation response of cavernosal strips were significantly restored by in vivo testosterone replacement but those induced by phenylephrine were not. Conclusion The lack of testosterone has an effect on the reactivity of the corpus cavernosum, indicating that testosterone has an important role in erectile function by a pre- or post-synaptic action on the corpus cavernosum.en_US
dc.language.isoengen_US
dc.publisherBLACKWELL SCIENCE LTDen_US
dc.relation.isversionof10.1046/j.1464-410X.1997.00175.xen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcorpus cavernosumen_US
dc.subjectcastrationen_US
dc.subjecttestosteroneen_US
dc.subjectcontractionen_US
dc.subjectrelaxationen_US
dc.subjectrabbit penisen_US
dc.titleEffects of castration on adrenergic, cholinergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbiten_US
dc.typearticleen_US
dc.relation.journalBRITISH JOURNAL OF UROLOGYen_US
dc.contributor.departmentCUMHURIYET UNIV,FAC MED,DEPT PHARMACOL,TR-58140 SIVAS,TURKEY -- RES LAB,SIVAS,TURKEYen_US
dc.identifier.volume79en_US
dc.identifier.issue6en_US
dc.identifier.endpage970en_US
dc.identifier.startpage964en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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