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dc.contributor.authorLeylek, OA
dc.contributor.authorUnlu, S
dc.contributor.authorOzturkcan, S
dc.contributor.authorCetin, A
dc.contributor.authorSahin, M
dc.contributor.authorYildiz, E
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:38:44Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:38:44Z
dc.date.issued1997
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.urihttps://dx.doi.org/10.1016/S0301-2115(96)02657-7
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11864
dc.descriptionWOS: A1997WL45300018en_US
dc.descriptionPubMed ID: 9076430en_US
dc.description.abstractThe aim of the present study was to evaluate the estrogen dermatitis of women who have chronic skin disorders with exacerbations or premenstrual dermatitis in a cyclic pattern. Twenty-three women exhibiting skin disorders of pruritus, urticaria, eczema, papulovesicular eruption, hirsutism-acne with hyperpigmentation (hirsutism and/or its related disorders such as acne) and 18 healthy control subjects were included in the study. Sensitivity to estrogen was described in 14 of 23 women. Of the 14 estrogen sensitive women, nine had a premenstrual flare of their skin lesions and five had a chronic dermatitis with exacerbations. In the evaluation of endocrine profile, mean serum testosterone and LH levels of the patient group were significantly higher than controls (2.814 +/- 0.839 vs. 1.561 +/- 0.645 nm/l, P < 0.001; 10.843 +/- 2.538 vs. 4.539 +/- 1.215 IU/l, P < 0.0001). The LH/FSH ratio of the patient group was also significantly higher than controls (1.765 +/- 0.329 vs. 0.810 +/- 0.116, P < 0.0001). Mean serum progesterone level of the patient group was significantly lower than the control group (0.499 +/- 0.201 vs. 0.977 +/- 0.396 ng/ml, P < 0.001). Hyperandrogenism and anovulation were the two more common outcomes in the patient group. Skin lesions of estrogen sensitive women were all cured with the administration of tamoxifen 20 mg daily for 7 days premenstrually. (C) 1997 Elsevier Science Ireland Ltd.en_US
dc.language.isoengen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.isversionof10.1016/S0301-2115(96)02657-7en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautoimmune diseaseen_US
dc.subjectdermatitisen_US
dc.subjectestrogenen_US
dc.subjectprogesteroneen_US
dc.subjectsensitization sex hormonesen_US
dc.subjecttamoxifenen_US
dc.titleEstrogen dermatitisen_US
dc.typearticleen_US
dc.relation.journalEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGYen_US
dc.contributor.departmentCUMHURIYET UNIV, SCH MED, DEPT DERMATOL, TR-58140 SIVAS, TURKEY -- CUMHURIYET UNIV, SCH MED, DEPT PATHOL, TR-58140 SIVAS, TURKEYen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894en_US
dc.identifier.volume72en_US
dc.identifier.issue1en_US
dc.identifier.endpage103en_US
dc.identifier.startpage97en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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