dc.contributor.author | Elibol, O | |
dc.contributor.author | Guler, C | |
dc.contributor.author | Arici, K | |
dc.contributor.author | Topalkara, A | |
dc.contributor.author | Demircan, S | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:38:45Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:38:45Z | |
dc.date.issued | 1997 | |
dc.identifier.issn | 0165-5701 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11869 | |
dc.description | 5th Congress of the European-Glaucoma-Society -- JUN 19-22, 1996 -- PARIS, FRANCE | en_US |
dc.description | WOS: A1997WT10600012 | en_US |
dc.description.abstract | It has been confirmed that topically applied bromocriptine has a satisfactory intraocular pressure (IOP) lowering effect without serious ocular or systemic side effects. We compared the IOP lowering effects of 0.05% bromocriptine and 0.25% timolol and determined whether they have an additive effect in lowering IOP in normal volunteers. In a double-blind, randomised, prospective, single-dose study, we measured IOP in 24 ocular normotensive subjects before (baseline) and 2, 4 and 6 hours after topical instillation of the following drugs: timolol and bromocriptine alone (n : 14), timolol + bromocriptine, timolol + placebo, bromocriptine + placebo (n : 10). Both bromocriptine and timolol have a significant IOP lowering effect (P < 0.01) compared with the baseline value during the study period. There were no significant differences in IOP lowering effect between timolol and bromocriptine at 2 and 4 hours (P > 0.05), but timolol was more efficacious than bromocriptine at 6 hours (p < 0.05). An additive effect in lowering IOP was not found. Although timolol and bromocriptine have no additive effect in lowering IOP, topically applied bromocriptine may be used in the treatment of glaucoma. | en_US |
dc.description.sponsorship | European Glaucoma Soc | en_US |
dc.language.iso | eng | en_US |
dc.publisher | KLUWER ACADEMIC PUBL | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | bromocriptine | en_US |
dc.subject | timolol | en_US |
dc.subject | intraocular pressure | en_US |
dc.subject | additive effect | en_US |
dc.title | The determination of additive effect and intraocular pressure lowering effects of 0.05% bromocriptine and 0.25% timolol | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL OPHTHALMOLOGY | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 01.Mar | en_US |
dc.identifier.endpage | 55 | en_US |
dc.identifier.startpage | 53 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |