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EFFECTS OF PROPOFOL ON VASCULAR SMOOTH-MUSCLE FUNCTION IN ISOLATED RAT AORTA

Date

1994

Author

MIMAROGLU, C
UTKAN, T
KAYA, T
KAFALI, H
SARIOGLU, Y

Metadata

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Abstract

This study was undertaken to determine the direct actions of propofol, and whether propofol exerts any action on basal endothelium-derived relaxing factor release and vasodilator effect of acetylcholine on phenylephrine-induced contractile responses in isolated rat aortic rings. This compound is known to produce a fall in blood pressure in man and animals, and it has been suggested that the hypotension may result from a direct vasodilator action on the veins and arterioles. In this study propofol did not induce any contractile response in aortic rings at various concentrations (10(-8)-10(-4) M). Propofol did not significantly alter phenylephrine-induced contractions at lower concentrations (10(-8)-10(-6)M) but at higher concentrations (10(-5)-10(-4)M) the depression caused by propofol was significant in both endothelium-intact and -denuded rings. Pretreatment of the endothelium-intact rings with propofol (10(-6) and 10(-5) M) produced a reduction in the relaxant effect of acetylcholine. The results obtained in this study demonstrate that clinically relevant concentrations of propofol (10(-6)M or less) have no direct vasodilator effects and that it reduces endothelium-dependent relaxation to acetylcholine.

Source

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Volume

16

Issue

4

URI

https://hdl.handle.net/20.500.12418/11951

Collections

  • Makale Koleksiyonu [5200]
  • Öksüz Yayınlar Koleksiyonu - WoS [6162]



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