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SELECTIVE-INHIBITION OF ENDOTHELIUM-DEPENDENT RELAXATION BY SYMPATHECTOMY IN RABBIT CAROTID-ARTERY RINGS INVITRO

Date

1993

Author

KARS, HZ
UTKAN, T
SARIOGLU, Y
YARADANAKUL, V

Metadata

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Abstract

The influence of cervical and periarterial sympathectomy on endothelium-dependent relaxation of the rabbit common carotid artery was studied in vitro. Noradrenaline, serotonin, acetylcholine and papaverine concentration-response curves of sympathectomized and control rabbit common carotid artery rings were recorded and analyzed and effects of endothelium removal were investigated. Endothelium-dependent relaxation was selectively and significantly inhibited in 3 weeks postsympathectomy arterial preparations. Alterations in acetylcholine receptors of endothelial cells, decrease in endothelium-derived relaxing factor synthesis, or desensitization of medial muscular cells to endothelium-derived relaxing factor are hypothetical causes of this phenomenon.

Source

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Volume

15

Issue

1

URI

https://hdl.handle.net/20.500.12418/11971

Collections

  • Makale Koleksiyonu [5200]
  • Öksüz Yayınlar Koleksiyonu - WoS [6162]



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