dc.contributor.author | Riaz, Muhammad Tariq | |
dc.contributor.author | Yaqub, Muhammad | |
dc.contributor.author | Shafiq, Zahid | |
dc.contributor.author | Ashraf, Abida | |
dc.contributor.author | Khalid, Muhammad | |
dc.contributor.author | Taslimi, Parham | |
dc.contributor.author | Tas, Recep | |
dc.contributor.author | Tuzun, Burak | |
dc.contributor.author | Gulçin, İlhami | |
dc.date.accessioned | 2022-05-13T09:05:50Z | |
dc.date.available | 2022-05-13T09:05:50Z | |
dc.date.issued | 5 June 2021 | tr |
dc.identifier.citation | a Institute of Chemical Sciences, Organic Chemistry Division, Bahauddin Zakariya University, Multan 60800, Pakistan
b Department of Chemistry, Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan 64200, Pakistan
c Department of Biotechnology, Faculty of Science, Bartin University, 74100 Bartin, Turkey
d Department of Chemistry, Faculty of Science, Istinye University, Istanbul, Turkey
e Department of Chemistry, Faculty of Science, Cumhuriyet University, 58140 Sivas, Turkey
f Department of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/13009 | |
dc.description.abstract | Some metabolic enzyme inhibitors can be used as Multi-target-Directed-Ligands (MTDL) in Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are essential. In this study, novel bisnapthoquinone derivatives (5a-o) were synthesized through a multi-component cascade reaction of two molecules of 2-hydroxy-1,4-naphthoquinone with an aromatic aldehyde in basic media using triethylamine as a catalyst. This novel heterocyclic derivatives (5a-o) are applied to inhibit the carbonic anhydrase (hCA I and hCA II) isoform in low levels of nano molecules with Ki values exist between 4.62 ± 1.01 to 70.45 ± 9.03 nM for hCA I and for hCA II which is physiologically dominant Kis values are in the range of 5.61 ± 1.04 to 73.26 ± 10.25 nM. Further these novel derivatives (5a-o) efficiently inhibit AChE with Ki values in the range of 0.13 ± 0.02 to 3.16 ± 0.56 nM. The compounds are also applied for BChE with Ki values varying between 0.50 ± 0.10 to 9.23 ± 1.15 nM. For α-glycosidase, the most efficient Ki values of 5e and 5f are 76.14 ± 9.60 and 95.27 ± 12.55 nM respectively. Finally, molecular docking calculations against enzymes (acetylcholinesterase, butyrylcholinesterase, and the human carbonic anhydrase I and II) are compared using biological activities of heterocyclic derivatives. After these calculations,an ADME/T analysis is performed to study the future medicinal use of heterocyclic derivatives from lawsone. | tr |
dc.language.iso | eng | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.subject | Lawson | tr |
dc.subject | Cascade synthesis | tr |
dc.subject | Enzyme inhibition | tr |
dc.subject | Molecular docking | tr |
dc.subject | ADME/T | tr |
dc.title | Synthesis, biological activity and docking calculations of bis-naphthoquinone derivatives from lawsone | tr |
dc.type | article | tr |
dc.contributor.department | Sivas Meslek Yüksekokulu | tr |
dc.identifier.volume | 114 | tr |
dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale | tr |