| dc.description.abstract | Abstract Öz
Purpose: In this study, the apoptosis marker M30, the
oxidative stress markers malondialdehyde, (MDA) and
asymmetric dimethyl arginine (ADMA) have been studied
in the context of endometriosis.
Materials and Methods: This prospective case-control
study comprises 31 patients diagnosed with endometriosis
and 31 controls. ADMA and M30 levels in blood serum
were measured by the enzyme-linked immunosorbent
assay (ELISA) method, and MDA levels were measured by
the spectrophotometric method. In addition, some
biochemical parameters and cancer antigen-125 (CA-125)
levels were also measured.
Results: M30 levels were statistically lower in
endometriosis patients (271.5 IU/L) than in controls
(371.3 IU/L). ADMA levels were higher in endometriosis
patients (19.3 ng/L) compared to controls (12.7 ng/L).
CA-125 levels were statistically higher in the endometriosis
patients (65.1 U/mL) compared to the controls (19.0
U/mL). There was no significant difference between the
two groups in MDA levels. The results regarding
dyspareunia, pelvic pain, AST, and ALP were statistically
significant.
Conclusion: In our study, decreased M30 levels in the
patient group were associated with reduced apoptosis in
endometriosis. ADMA levels, elevated with the increase of
oxidative stress, were higher in the patients. MDA levels,
an indicator of increased oxidative stress, were also higher
in the patient group. This study constitutes the first data
regarding endometriosis patients' ADMA, M30, and MDA
levels. | tr |
