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dc.contributor.authorSarkı, Gülpınar
dc.contributor.authorTüzün,Burak
dc.contributor.authorÜnlüer, Dilek
dc.contributor.authorKantekin, Halit
dc.date.accessioned2024-01-09T12:16:53Z
dc.date.available2024-01-09T12:16:53Z
dc.date.issued23 July 2022tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14222
dc.description.abstractDifferent properties of phthalocyanine compounds can be measured both theoretically and experimentally. In this study, tetra substituted phthalocyanines (H2 (2) and CuII (3) were performed using 4-(4-(4-methoxyphenethyl)-3-benzyl-5-oxo-4,5-dihydro-1,2,4 triazol-1-yl)phthalonitrile (1). The structures of all these original compounds synthesized were elucidated using distinctive of spectroscopic techniques.Theoretical comparison of the chemical and biological activities of phthalocyanine molecules and its copper metal complex has been made. Chemical activities were compared with Gaussian software program and biological activities were compared with molecular docking calculations. Used proteins for biological activity are the crystal structure of estrogen receptor protein (from the breast cancer), ID: 1A52, crystal structure of VEGFR kinase protein (from liver cancer), ID: 3WZE, crystal structure of MLK4 kinase (colon cancer) ID: 4UYA, and crystal structure of an allosteric Eya2 phosphatase inhibitor protein (from lung cancer), ID: 5ZMA. After, the interactions between molecules and proteins were determined using the Protein-Ligand Interaction Profiler (PLIP) servertr
dc.language.isoengtr
dc.publisherInorganica Chimica Actatr
dc.relation.isversionofhttps://doi.org/10.1016/j.ica.2022.121113tr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectPhthalocyaninetr
dc.subjectMolecular dockingtr
dc.subjectADME/Ttr
dc.subjectDFTtr
dc.titleSynthesis, characterization, chemical and biological activities of 4-(4-methoxyphenethyl)-5- benzyl-2-hydroxy-2H-1,2,4-triazole-3(4H)-one phthalocyanine derivativestr
dc.typearticletr
dc.contributor.departmentSivas Meslek Yüksekokulutr
dc.identifier.volume545tr
dc.identifier.startpage121113tr
dc.relation.publicationcategoryUluslararası Editör Denetimli Dergide Makaletr


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