IgA Nephropathy: A Rare lesion in renal biopsy in systemic lupus erythematosus: Case reports and review of literature

Abstract

Sistemik lupus eritematozusta (SLE) morbidite ve mortaliteyi arttıran lupus nefritine (LN) sık olarak rastlanır. Lupus nefritinde böbrek biyopsisinde; minimal glomerüler lezyonlar, mezengioproliferatif, fokal proliferatif, membranöz ve diffüz proliferatif glomerülonefrit görülebilmektedir. Ancak SLE’de nadiren non-lupus nefritler de bildirilmiştir. Non-lupus nefritlerde en sık fokal segmental glomerüloskleroz görülmekle birlikte nadiren IgA nefropatiside (IgANP) bildirilmiştir. Bu yazıda böbrek biyopsisinde IgANP saptanan bir SLE olgusu sunulmuştur.

Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE). Lupus nephritis is a frequent complication of SLE that increases mortality and morbidity. Minimal glomerular lesions, mesangial proliferative, focal proliferative, membranous and diffuse glomerulonephritis can be seen in renal biopsies of patients with lupus nephritis. It has been reported that non-lupus nephritis can also rarely occur in SLE. While non-lupus nephritis cases usually manifest as focal segmental glomerulosclerosis, they have been seen rarely as IgA nephropathy. In this paper, we have represented a SLE case with IgA nephropathy on renal biopsy.