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Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats
(TAYLOR & FRANCIS LTD, 2011)
Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate ...
Zimelidine attenuates the development of tolerance to morphine-induced antinociception
(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2012)
Objectives: The aim of this study was to investigate effect of zimelidine (a serotonin reuptake inhibitor) on morphine-induced tolerance in rats. Materials and Methods: Male Wistar albino rats weighing 160-180 g were used ...