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Mechanism of relaxation induced by nicotine in normal and ovalbumin-sensitized guinea-pig trachea
(ELSEVIER SCIENCE BV, 2007)
Nicotine is an irritant molecule in the cigarette that contributes airway hyper-reactivity. The aim of this study was to investigate the mechanism of these effects and effects of nicotine on the isolated trachea preparations ...
Investigation of the relaxant effects of pinacidil and Cromakalim on the sheep sphincter of Oddi
(KARGER, 2006)
Background/Aims: ATP-sensitive K+ (KATP) channels play an important role in the regulation of smooth muscle membrane potential. This study was designed to investigate the effects of pinacidil and cromakalim, KATP-sensitive ...
Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis
(W J G PRESS, 2009)
AIM: To investigate in vitro effects of propofol, midazolam and dexmedetomidine, which are commonly used anaesthesic or sedatives, on spontaneous contractions of the ileum both in normal rats and those exposed to hyperdynamic ...
Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi
(KARGER, 2006)
Background/Aims: Nitric oxide (NO) is a major inhibitor in various parts of the gastrointestinal tract. This study was designed to compare the effects of YC-1, NO-independent soluble guanylate cyclase (sGC) activator, and ...
Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception
(ELSEVIER SCIENCE BV, 2007)
Nimesulide, celecoxib, and DFU (5, 5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone) are nonsteroidal antiinflammatory drugs (NSAIDs) with selective cyclo-oxygenase (COX)-2 blocking properties and ...
Investigation of relaxant effects of propofol on sheep sphincter of Oddi
(KARGER, 2007)
Background/Aims: Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangio-pancreatography ( ERCP) and endoscopic sphincter of Oddi ( SO) manometry. This study was designed to investigate ...
The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model
(ELSEVIER SCIENCE BV, 2008)
The pathophysiology of pre-eclampsia is still unknown thus effective primary prevention is not possible at the stage. The present study was conducted to research the smooth muscle responses in the pre-eclampsia model with ...
Alterations in spontaneous contractions of rat proximal and distal colon after peritonitis
(W B SAUNDERS CO-ELSEVIER INC, 2007)
Background/ Purpose: The aim of this study was to investigate the effect of peritonitis on spontaneous contractions of distal and proximal colon smooth muscle isolated from rats. Methods: Peritonitis was induced by cecal ...
Investigation of the relaxant effects of pancuronium, rocuronium, vecuronium and mivacurium on rat thoracic aorta
(LIPPINCOTT WILLIAMS & WILKINS, 2009)
Background and objective Pancuronium, vecuronium, mivacurium and rocuronium are nondepolarizing neuromuscular blocking agents, which are competitive antagonists against acetylcholine at nicotinic receptors, and considered ...
Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter
(BAISHIDENG PUBL GRP CO LTD, 2008)
AIM: To investigate the tolerance development against the relaxant effect of nitric oxide donating drug isosorbide dinitrate (ISDN) and sodium nitropruside (SNP) in internal anal sphincter (IAS) smooth muscle. METHODS: ...