Search
Now showing items 1-4 of 4
Effect of salt bridge on transcription activation of CRP-dependent lactose operon in Escherichia coli
(ELSEVIER SCIENCE INC, 2006)
Expression of catabolite-sensitive operons in Escherichia coli is cAMP-dependent and mediated through the CRP:cAMP complex binding to specific sequences in DNA. Five specific ionic or polar interactions occur in cAMP binding ...
Heat shock proteins, substrate specificity and modulation of function
(BENTHAM SCIENCE PUBL LTD, 2006)
Hsp70 is a universally conserved essential protein chaperone. In addition to its roles in many cellular process, Hsp70 protects cells from stress by binding partially unfolded proteins. Therefore, Hsp70 prevents protein ...
CRP subunit association and hinge conformation changes in response to cAMP binding: Analysis of C-helix cysteine-substituted CRP
(AMER CHEMICAL SOC, 2006)
We investigated the characteristics of 13 CRP variants having cysteine substituted at positions 113, 115, 116, 117, 118, 120, 122, 124, 126, 127, 129, 130, or 131, positions that span the length of the CRP C alpha-helix. ...
Key residues involved in Hsp70 regulatory activity and affect of co-chaperones on mechanism of action
(BENTHAM SCIENCE PUBL LTD, 2006)
Hsp70 proteins assist refolding of polypeptides in an ATP dependent manner. Crystal structure of intact Hsp70 protein has not been determined yet however, structures of its two domains were solved separately. Allostery ...