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Effect of Levosimendan in Patients with Severe Systolic Heart Failure and Worsening Renal Function
(ARQUIVOS BRASILEIROS CARDIOLOGIA, 2012)
Background: Levosimendan, a calcium sensitizer, increases the sensitivity of the heart to calcium, thus increasing myocardial contractility without a rise in intracellular calcium. It was recently shown that levosimendan ...
Frequency of the mdr-1 C > T gene polymorphism in patients with COPD
(HOSPITAL CLINICAS, UNIV SAO PAULO, 2010)
BACKGROUND AND AIM: The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the ...