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miRNA and Cancer; Computational and Experimental Approaches
(BENTHAM SCIENCE PUBL LTD, 2014)
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Therapeutic Targeting of microRNAs in Cancer: Future Perspectives
(WILEY-BLACKWELL, 2015)
The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18-24 nucleotides long, miRNAs can up-regulate or down-regulate gene expression in many cancer types ...
Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
(BENTHAM SCIENCE PUBL LTD, 2016)
Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target ...
Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor Protein
(PUBLIC LIBRARY SCIENCE, 2013)
Escherichia coli cyclic AMP Receptor Protein (CRP) undergoes conformational changes with cAMP binding and allosterically promotes CRP to bind specifically to the DNA. In that, the structural and dynamic properties of apo ...
CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands
(TAYLOR & FRANCIS LTD, 2016)
Carbon monoxide (CO) is an important signaling molecule which plays significant roles in the pathogenesis of cancer. CO is produced by enzymatic degradation of heme in mammals. Heme oxygenase 1 (HO-1) catalyzes the breakdown ...
Pseudogenes
(HINDAWI PUBLISHING CORPORATION, 2012)
Pseudogenes are ubiquitous and abundant in genomes. Pseudogenes were once called "genomic fossils" and treated as "junk DNA" several years. Nevertheless, it has been recognized that some pseudogenes play essential roles ...
Therapeutic Proteins: A to Z
(BENTHAM SCIENCE PUBL LTD, 2013)
In recent years, therapeutic proteins have become an important growing class of drugs in the pharmaceutics industry. The development of recombinant DNA technology has caused to appreciation of therapeutic value of many ...
Thematic Issue: Controlled Release and Drug Delivery in Diseases
(BENTHAM SCIENCE PUBL LTD, 2014)
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Heat shock protein 70 purification and characterization from Cyprinion macrastomus macrastomus and Garra rufa obtusa
(PERGAMON-ELSEVIER SCIENCE LTD, 2012)
Organisms resist stress factors by common mechanisms at cellular and physiological levels. Heat shock proteins (Hsps) play an essential role as a protective mechanism against stressors, and Hsp70 has a central role in the ...
Isolation and Identification of Free-Living Amoebae from Tap Water in Sivas, Turkey
(HINDAWI PUBLISHING CORPORATION, 2013)
The present work focuses on a local survey of free-living amoebae (FLA) that cause opportunistic and nonopportunistic infections in humans. Determining the prevalence of FLA in water sources can shine a light on the need ...