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Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure

Mebazaa, Alexandre; Laterre, Pierre Francois; Russell, James A.; Bergmann, Andreas; Gattinoni, Luciano; Gayat, Etienne; Harhay, Michael O.; Hartmann, Oliver; Hein, Frauke; Kjolbye, Anne Louise; Legrand, Matthieu; Lewis, Roger J.; Marshall, John C.; Marx, Gernot; Radermacher, Peter; Schroedter, Mathias; Scigalla, Paul; Stough, Wendy Gattis; Struck, Joachim; Van den Berghe, Greet; Yilmaz, Mehmet Birhan; Angus, Derek C. (BMC, 2016)

Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategies have failed ...

Comparison of Ultrafiltration and Intravenous Diuretic Therapies in Patients Hospitalized for Acute Decompensated Biventricular Heart Failure

Seker, Ayse; Kayatas, Mansur; Huzmeli, Can; Candan, Ferhan; Yilmaz, Mehmet Birhan (TURK NEFROLOJI DIYALIZ TRANSPLANTASYON DERGISI, 2016)

OBJECTIVE: Studies comparing ultrafiltration and diuretics in management of ADHF have shown controversial results. In this study, we compared the efficacy and safety of intravenous diuretic therapy and ultrafiltration in ...

Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper

Farmakis, Dimitrios; Alvarez, Julian; Ben Gal, Tuvia; Brito, Dulce; Fedele, Francesco; Fonseca, Candida; Gordon, Anthony C.; Gotsman, Israel; Grossini, Elena; Guarracino, Fabio; Harjola, Veli-Pekka; Hellman, Yaron; Heunks, Leo; Ivancan, Visnja; Karavidas, Apostolos; Kivikko, Matti; Lomivorotov, Vladimir; Longrois, Dan; Masip, Josep; Metra, Marco; Morelli, Andrea; Nikolaou, Maria; Papp, Zoltan; Parkhomenko, Alexander; Poelzl, Gerhard; Pollesello, Piero; Ravn, Hanne Berg; Rex, Steffen; Riha, Hynek; Ricksten, Sven-Erik; Schwinger, Robert H. G.; Vrtovec, Bojan; Yilmaz, M. Birhan; Zielinska, Marzenna; Parissis, John (ELSEVIER IRELAND LTD, 2016)

Levosimendan is a positive inotrope with vasodilating properties (inodilator) indicated for decompensated heart failure (HF) patients with low cardiac output. Accumulated evidence supports several pleiotropic effects of ...

Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance

Mebazaa, A.; Tolppanen, H.; Mueller, C.; Lassus, J.; DiSomma, S.; Baksyte, G.; Cecconi, M.; Choi, D. J.; Solal, A. Cohen; Christ, M.; Masip, J.; Arrigo, M.; Nouira, S.; Ojji, D.; Peacock, F.; Richards, M.; Sato, N.; Sliwa, K.; Spinar, J.; Thiele, H.; Yilmaz, M. B.; Januzzi, J. (SPRINGER, 2016)

Purpose: Acute heart failure (AHF) causes high burden of mortality, morbidity, and repeated hospitalizations worldwide. This guidance paper describes the tailored treatment approaches of different clinical scenarios of AHF ...

Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology

Harjola, Veli-Pekka; Mebazaa, Alexandre; Celutkiene, Jelena; Bettex, Dominique; Bueno, Hector; Chioncel, Ovidiu; Crespo-Leiro, Maria G.; Falk, Volkmar; Filippatos, Gerasimos; Gibbs, Simon; Leite-Moreira, Adelino; Lassus, Johan; Masip, Josep; Mueller, Christian; Mullens, Wilfried; Naeije, Robert; Nordegraaf, Anton Vonk; Parissis, John; Riley, Jillian P.; Ristic, Arsen; Rosano, Giuseppe; Rudiger, Alain; Ruschitzka, Frank; Seferovic, Petar; Sztrymf, Benjamin; Vieillard-Baron, Antoine; Yilmaz, Mehmet Birhan; Konstantinides, Stavros (WILEY, 2016)

Acute right ventricular (RV) failure is a complex clinical syndrome that results from many causes. Research efforts have disproportionately focused on the failing left ventricle, but recently the need has been recognized ...

Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens

Senni, Michele; McMurray, John J. V.; Wachter, Rolf; McIntyre, Hugh F.; Reyes, Antonio; Majercak, Ivan; Andreka, Peter; Shehova-Yankova, Nina; Anand, Inder; Yilmaz, Mehmet B.; Gogia, Harinder; Martinez-Selles, Manuel; Fischer, Steffen; Zilahi, Zsolt; Cosmi, Franco; Gelev, Valeri; Galve, Enrique; Gomez-Doblas, Juanjo J.; Nociar, Jan; Radomska, Maria; Sokolova, Beata; Volterrani, Maurizio; Sarkar, Arnab; Reimund, Bernard; Chen, Fabian; Charney, Alan (WILEY, 2016)

AimsTo assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction 35%). Methods and ...