Morphology of the esophago-duodenal anastomotic region after total gastrectomy: Early changes
Abstract
Total gastrectomy is considered to be a major treatment for gastric cancer. The aim of the present study was to investigate the possible effects of total gastrectomy on the esophago-duodenal anastomotic region morphology along with the determination of carcinoembryonic antigen (CEA) immunoreactivity during the early period. A series of rats underwent total gastrectomy via esophago-duodenostomy. Thirty days postoperatively, the morphology of the esophago-duodenal anastomotic region was determined at the light and electron microscopical levels. Esophago-duodenal anastomotic region samples were stained with hematoxylin-eosin and colloidal iron-PAS. In addition, CEA immunolocalization was also investigated. In the duodenal site of the anastomotic region, there were intervillous fusions along with a decrease in villous height and goblet cell secretory activity. There were neoplastic glands in the submucosa of esophagus and duodenum and their secretions were PAS positive. CEA immunoreactivity was observed widely in the cellular membrane surface surrounding the neoplastic glands, in their products, and in the connective tissue of the glands. It is likely that total gastrectomy causes adverse morphological changes throughout the esophago-duodenal anastomotic region. Strong CEA immunoreactivity may be a relevant marker for potential anastomotic region cancer in the early postoperative period after total gastrectomy. © Springer-Verlag London Limited 2006.
Source
Comparative Clinical PathologyVolume
15Issue
1Collections
- Makale Koleksiyonu [5745]