A comparison of propofol with propofol-alfentanil using patient controlled sedation [Hasta kontrollü sedasyonda propofol ve propofol-alfentanil'in karşilaştirilmasi]

Abstract

The aim of this study was to compare Patient Controlled Sedation with propofol or a propofol-alfentanil combination in patients undergoing urologic endoscopic procedures under spinal anesthesia. The study was carried out on 50 male ASA I or II patients aged 35-75. Group I (n=25) received 0.3 mg kg-1 propofol, Group II (n=25) recevied 0.2 mg kg-1 propofol and 2 ?g kg-1 alfentanil using a patient controlled sedation device. Heart rate, mean arterial pressure, SpO2, respiratory rate, anxiety and sedation degrees were recorded before sedation, at the 15th and 30th minute of sedation and at the postoperative 30th minute. At the end of the operation, patient satisfaction, recovery time and presence of amnesia were assessed. Sedation scores were within desirable levels in both groups, but there was no difference in the sedation scores. While preoperative anxiety scores were high, peroperative and postoperative scores decreased significantly. There was no difference between the groups in recovery scores or patient satisfaction. None of the patients had amnesia during sedation. The adverse effects noted were 52% in group I, 24% in group II. It was concluded that there are no differences in sedation, anxiety, recovery scores and hemodynamic effects between the groups. We think that the propofol-alfentanil combination is superior since its adverse effects were fewer.