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dc.contributor.authorAyan S.
dc.contributor.authorKalo?lu C.
dc.contributor.authorGökçe G.
dc.contributor.authorUçar C.
dc.contributor.authorKiliçarslan H.
dc.contributor.authorGültekin E.Y.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:13:17Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:13:17Z
dc.date.issued1999
dc.identifier.issn0036-5599
dc.identifier.urihttps://hdl.handle.net/20.500.12418/4661
dc.description.abstractObjective: To investigate the efficacy of insulin therapy in preventing cystopathic changes in diabetes using a rabbit model. Materials and Methods: Twenty-four New Zealand white rabbits were studied in three groups: eight in group 1 as control, eight in group 2 with diabetes by administration intravenously alloxan hydrochloride and eight in group 3 administered insulin therapy after induction of diabetes. Urodynamic investigations were carried out in three groups at the end of 8 weeks. Tissue sections prepared from all groups were studied histologically. Results: Bladder capacity and compliance increased in diabetic non-treated group. There was no significant difference between the control group and the diabetic group treated with insulin. The neuropathic changes were observed in the diabetic group, whereas the findings of the histological study were similar in the control and in the insulin treatment group. Conclusions: This animal model indicates that insulin therapy can prevent or delay urodynamic and histopathological changes in diabetes mellitus. These results must be supported by in vitro pharmacological studies.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCystopathyen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectExperimental diabetic rabbitsen_US
dc.subjectUrinary bladderen_US
dc.subjectUrodynamic investigationen_US
dc.titleEffect of insulin therapy for diabetic cystopathy: Urodynamic and histological findings in a rabbit modelen_US
dc.typearticleen_US
dc.relation.journalScandinavian Journal of Urology and Nephrologyen_US
dc.contributor.departmentAyan, S., Department of Urology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Kalo?lu, C., Department of Histology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Gökçe, G., Department of Urology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey, Cumhuriyet Üniv., Tip Fak., Hastanesi Üroloji Anabilim, Dali, TR-58140 Sivas, Turkey -- Uçar, C., Department of Urology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Kiliçarslan, H., Department of Urology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Gültekin, E.Y., Department of Urology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkeyen_US
dc.identifier.volume33en_US
dc.identifier.issue6en_US
dc.identifier.endpage395en_US
dc.identifier.startpage392en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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