| dc.description.abstract | We investigated the effect of 16,16-dimethyl prostaglandin E2 indomethacin and Ginkgo biloba extract on the survival in two experimental sepsis models in rats due to administration of 1 x 107 cfu and 1 x 109 cfu Escherichia coli. Animals in each model were then randomly divided (10/group) into four groups, administered saline, indomethacin, G. biloba extract and prostaglandin E2 respectively. When compared, there was no significant difference in the survival period between the two sepsis models (P > 0.05). The best survival rate was observed in the PGE2-administered animals in the first major model (P < 0.05). Indomethacin appeared not to decrease the mortality rates. There was no significant difference in PGE2 levels between two sepsis models (P > 0.05). Our results suggest that elevated prostaglandin E2 levels following major trauma are not responsible for the postinjury increased susceptibility to infectious complications. Our observations should also discourage aggressive use of cyclo-oxygenase inhibitors for protection against infectious complications after major trauma. | en_US |
| dc.contributor.department | Cantürk, N.Z., Kocaeli University, Faculty of Medicine, Department of Surgery, Kocaeli, Turkey, Köcaeli Üniversitesi, Tip Fak, Genel Cerrahi Anabilim Dali S., Derince Kocaeli, Turkey -- Utkan, N.Z., Kocaeli University, Faculty of Medicine, Department of Surgery, Kocaeli, Turkey -- Cantürk, Z., Cumhuriyet University, Faculty of Medicine, Department of Internal Medicine, Sivas, Turkey -- Yenisey, C., Aydin Menderes University, Faculty of Medicine, Department of Biochemistry, Aydins, Turkey -- Yildirir, C., Cumhuriyet University, Faculty of Medicine, Department of Surgery, Sivas, Turkey -- Dülger, M., Kocaeli University, Faculty of Medicine, Department of Surgery, Kocaeli, Turkey | en_US |
