Effects of two calcium channel blockers on aminoglycoside nephrotoxicity
Abstract
The effects of nitrendipine (dihydropyridine) and verapamil (phenalalkylamin), which are structurally dissimilar in the calcium channel blockers, on rat model gentamicin-induced nephrotoxicity were investigated. Both drugs showed no beneficial effects on gentamicin nephrotoxicity according to biochemical parameters, and caused no changes on renal histopathology. These results indicated that calcium channel blockage with nitrendipine or verapamil has no protective effect on aminoglycoside nephrotoxicity.
Source
Turkish Journal of Medical SciencesVolume
25Issue
4Collections
- Makale Koleksiyonu [5745]