| dc.description.abstract | We have studied the effects of some H2-receptor antagonists (i.e., cimetidine, famotidine) taken with alcohol on lipid peroxidation (LP) in the erythrocyte membrane, liver and stomach tissue of rats in vivo. Rats were given ethanol after receiving cimetidine or famotidine for nine days. Malondialdehyde (MDA) levels were determined with the thiobarbituric acid test procedure. Results were compared with the groups receiving only ethanol or nothing as control. MDA levels of the erythrocyte membrane and liver tissue increased significantly in the cimetidine group compared with the famotidine group (p < 0.05). However, there was no difference found between the famotidine group and the group receiving only ethanol (p > 0.05). MDA levels of the stomach tissue decreased in both the cimetidene and famotidine groups compared with the ethanol group (p < 0.05). Our results suggest that some H2-receptor antagonists (i.e., cimetidine) increase LP levels in some body tissues if they are taken with acute alcohol. Furthermore, they can cause some unwanted harmful effects by increasing serum alcohol concentrations. | en_US |
| dc.contributor.department | Candan, F., Department of Biochemistry, Faculty of Art and Science, Cumhuriyet University, Sivas, Turkey, Department of Biochemistry, Faculty of Art and Science, Cumhuriyet University, Sivas, Turkey -- Candan, F., Department of Biochemistry, Faculty of Art and Science, Cumhuriyet University, Sivas, Turkey, Department of Biochemistry, Faculty of Art and Science, Cumhuriyet University, Sivas, Turkey -- Oztop, H.N., Department of Biochemistry, Faculty of Art and Science, Cumhuriyet University, Sivas, Turkey | en_US |
