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dc.contributor.authorKaya T.
dc.contributor.authorUtkan T.
dc.contributor.authorSarioglu Y.
dc.contributor.authorGoksel M.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:13:49Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:13:49Z
dc.date.issued1995
dc.identifier.issn0379-0355
dc.identifier.urihttps://hdl.handle.net/20.500.12418/4800
dc.description.abstractThe influence of cervical and periarterial sympathectomy on endothelium-dependent and endothelium-independent relaxations of the mature rabbit carotid artery was studied in vitro. The responses to adenosine, vasoactive intestinal polypeptide and substance P in sympathectomized and control rabbit carotid artery rings were recorded and analyzed. The effects of endothelium removal were also investigated. The maximal relaxation achieved by substance P, which produces endothelium-dependent relaxation, was significantly inhibited in 3 weeks in postsympathectomy arterial preparations as compared to controls. Adenosine and vasoactive intestinal polypeptide, which produce endothelium-independent relaxation, elicited similar relaxation in all tissues. These results demonstrated that the response to substance P was impaired by cervical and periarterial sympathectomy. The decreased maximum response to substance P may be the result of a decreased NX-1 receptor subtype density or excitation/response coupling, or it may be due to an impaired production and/or liberation of endothelium-derived relaxing factor (EDRF).en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadenosineen_US
dc.subjectcarotid arteryen_US
dc.subjectsubstance Pen_US
dc.subjectsympathectomyen_US
dc.subjectVIPen_US
dc.titleAltered endothelium-mediated relaxation by sympathectomy in isolated rabbit carotid artery ringsen_US
dc.typearticleen_US
dc.relation.journalMethods and Findings in Experimental and Clinical Pharmacologyen_US
dc.contributor.departmentKaya, T., Cumhuriyet University, Faculty of Medicine, Department of Pharmacology, 58140 Sivas, Turkey -- Utkan, T., Cumhuriyet University, Faculty of Medicine, Department of Pharmacology, 58140 Sivas, Turkey -- Sarioglu, Y., Cumhuriyet University, Faculty of Medicine, Department of Pharmacology, 58140 Sivas, Turkey -- Goksel, M., Cumhuriyet University, Faculty of Medicine, Department of Pharmacology, 58140 Sivas, Turkeyen_US
dc.identifier.volume17en_US
dc.identifier.issue6en_US
dc.identifier.endpage375en_US
dc.identifier.startpage369en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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