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dc.contributor.authorSarioglu Y.
dc.contributor.authorUtkan T.
dc.contributor.authorUtkan N.Z.
dc.contributor.authorBozkurt A.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:13:57Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:13:57Z
dc.date.issued1993
dc.identifier.issn0379-0355
dc.identifier.urihttps://hdl.handle.net/20.500.12418/4830
dc.description.abstractTo understand the effects of diabetes on vascular smooth muscle function and the underlying mechanisms involved, we examined the responses to noradrenaline (NA), serotonin, KCl and acetylcholine in the femoral artery of mongrel dogs with chronic diabetes (3 months)-induced subtotal pancreatectomy. Isolated ring segments of diabetic dog femoral artery exhibited an increased response to serotonin, a decreased response to NA, an unchanged response to KCl and a decreased endothelium-dependent relaxation to acetylcholine as compared with controls. The sensitivity (pD2) of diabetic femoral artery rings to NA and serotonin was markedly diminished. These results suggest that changed responsiveness of arteries from diabetic animals to NA, serotonin and acetylcholine could be the reflection of an alteration in the contractile machinery or the result of a decrease in endothelium- derived relaxing factor release in diabetic blood vessels.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of chronic experimental diabetes on vascular smooth muscle function in dog femoral arteryen_US
dc.typearticleen_US
dc.relation.journalMethods and Findings in Experimental and Clinical Pharmacologyen_US
dc.contributor.departmentSarioglu, Y., Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Utkan, T., Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Utkan, N.Z., Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Bozkurt, A., Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkeyen_US
dc.identifier.volume15en_US
dc.identifier.issue3en_US
dc.identifier.endpage167en_US
dc.identifier.startpage161en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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