Show simple item record

Is there a role for TNF-? antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique

dc.contributor.authorDistler J.H.W.
dc.contributor.authorJordan S.
dc.contributor.authorAirò P.
dc.contributor.authorAlegre-Sancho J.J.
dc.contributor.authorAllanore Y.
dc.contributor.authorBalbir Gurman A.
dc.contributor.authorCaporali R.
dc.contributor.authorCaramaschi P.
dc.contributor.authorCarreira P.E.
dc.contributor.authorChizzolini C.
dc.contributor.authorCutolo M.
dc.contributor.authorTuncay Duruöz M.
dc.contributor.authorFarge-Bancel D.
dc.contributor.authorHesselstrand R.
dc.contributor.authorIannone F.
dc.contributor.authorDe Keyser F.
dc.contributor.authorKucharz E.J.
dc.contributor.authorLaunay D.
dc.contributor.authorGarcía De La Peña Lefebvre P.
dc.contributor.authorLukacova O.
dc.contributor.authorMarasini B.
dc.contributor.authorMartinovic D.
dc.contributor.authorMarques Neto J.F.
dc.contributor.authorRadic M.
dc.contributor.authorRednic S.
dc.contributor.authorRiemekasten G.
dc.contributor.authorRovensky J.
dc.contributor.authorSeidel M.F.
dc.contributor.authorSenel S.
dc.contributor.authorSmith V.
dc.contributor.authorSunderkötter C.
dc.contributor.authorTon E.
dc.contributor.authorVan Laar J.M.
dc.contributor.authorMatucci-Cerinic M.
dc.contributor.authorMüller-Ladner U.
dc.contributor.authorDistler O.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:15:04Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:15:04Z
dc.date.issued2011
dc.identifier.issn0392856X
dc.identifier.urihttps://hdl.handle.net/20.500.12418/5029
dc.description.abstractObjective: To obtain experiences and expert opinion on treatment of SSc patients with TNF-? antagonists. Methods: An investigation was carried out among the EUSTAR centres into their expertise on use of TNF-? antagonists. Assessment forms on the frequency of TNF-? inhibitor use were distributed to EULAR Scleroderma Trials and Research Group (EUSTAR) centres. Afterwards, a three round Delphi exercise was performed to obtain expert consensus on the use of TNF-? inhibitors in SSc. Results: Seventy-nine centres returned information on use of TNF-? antagonists in SSc patients. A total of 65 patients were treated with TNF-a inhibitors in 14 different centres. Forty-eight of the 65 patients treated with TNF-? inhibitors improved. Improvement was mainly seen in patients with arthritis, whereas the effects on fibrosis varied. In the first round of the subsequent Delphi approach, 71 out of 79 experts stated that they would use TNF-? antagonists in SSc. Arthritis was suggested as an indication for TNFa antagonists by 75% of the experts. However, after the third stage of the Delphi exercise, the acceptance for the off-label use of TNF-a antagonists decreased and 59% recommended that TNF-? antagonists should not be used or only used in clinical trials in SSc patients, while 38% of the experts suggested the use of TNF-a antagonists for arthritis associated with SSc. Conclusions: Most of the experts do not recommend the routine use of TNF-a antagonists in systemic sclerosis. Arthritis might be a potential indication in SSc, although controlled clinical trials with TNF-? antagonists are needed before general recommendations can be given. © Copyright Clinical and Experimental Rheumatology 2011.en_US
dc.description.sponsorshipDistler, O.; Department of Rheumatology, University Hospital Zurich, Gloriastr. 25, 8091 Zürich, Switzerland; email: oliver.distler@usz.chen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibrosisen_US
dc.subjectSclerodermaen_US
dc.subjectTNF-?en_US
dc.titleIs there a role for TNF-? antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi techniqueen_US
dc.typearticleen_US
dc.relation.journalClinical and Experimental Rheumatologyen_US
dc.contributor.departmentDistler, J.H.W., Department of Rheumatology, University of Erlangen-Nuremberg, Germany -- Jordan, S., Department of Rheumatology, University Hospital Zurich, Gloriastr. 25, 8091 Zürich, Switzerland -- Airò, P., Unit of Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy -- Alegre-Sancho, J.J., Hospital Universitario Dr. Peset Valencia, Spain -- Allanore, Y., Université Paris Descartes, Service de Rhumatologie A, Hôpital Cochin, Paris, France -- Balbir Gurman, A., B. Shine Rheumatology Unit, Rambam Health Care Campus, Haifa, Israel -- Caporali, R., Division of Rheumatology, University of Pavia, Matteo Foundation, Pavia, Italy -- Caramaschi, P., Rheumatology Unit, Verona, Italy -- Carreira, P.E., Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain -- Chizzolini, C., Immunology and Allergy, University Hospital, Geneva, Switzerland -- Cutolo, M., Research Laboratory and Academic Unit of Clinical Rheumatology, Dept. Internal Medicine, University of Genova, Italy -- Tuncay Duruöz, M., Celal Bayar University Medical School, PM and R Department, Rheumatology Division, Manisa, Turkey -- Farge-Bancel, D., Service de Médecine Interne et Pathologie Vasculaire, Inserm U976, Hopital Saint-Louis, Paris, France -- Hesselstrand, R., Department of Rheumatology, Lund University Hospital, Lund, Sweden -- Iannone, F., DiMIMP - Rheumatology Unit, University of Bari, Italy -- De Keyser, F., Department of Rheumatology, Ghent University Hospital, Belgium -- Kucharz, E.J., Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland -- Launay, D., Department of Internal Medicine, Lille 2 University, Lille, France -- García De La Peña Lefebvre, P., Hospital Universitario Madrid Norte Sanchinarro, Spain -- Lukacova, O., National Institute for Rheumatic Diseases, Piešt' any, Slovakia -- Marasini, B., Istituto Clinico Humanitas, University of Milan, Italy -- Martinovic, D., Department of Rheumatology, University Hospital Split, Split, Croatia -- Marques Neto, J.F., FCM-UNICAMP, Campinas, SP, Brazil -- Radic, M., Department of Rheumatology, University Hospital Split, Split, Croatia -- Rednic, S., Clinica Reumatologie, University of Medicine and Pharmacy, Iuliu Hatieganu Cluj, Cluj-Napoca, Romania -- Riemekasten, G., Charité- Universitätsmedizin Berlin, Medizinische Klinik Mit Schwerpunkt Rheumatologie und Klinische Immunologie, Berlin, Germany -- Rovensky, J., National Institute for Rheumatic Diseases, Piešt' any, Slovakia -- Seidel, M.F., Medizinische Klinik und Poliklinik 1, Rheumatology, Bonn, Germany -- Senel, S., Cumhuriyet University, School of Medicine, Division of Rheumatology, Sivas, Turkey -- Smith, V., Department of Rheumatology, Ghent University Hospital, Belgium -- Sunderkötter, C., Department of Dermatology, University Hospital Münster, Münster, Germany -- Ton, E., Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Netherlands -- Van Laar, J.M., Musculoskeletal Research Group, Institute of Cellular Medicine, Medical School, Newcastle upon Tyne, United Kingdom -- Matucci-Cerinic, M., Department of Biomedicine, Division of Rheumatology AOUC, University of Florence, Florence, Italy -- Müller-Ladner, U., Justus-Liebig University Giessen, Department of Rheumatology and Clinical Immunology, Kerckhoff Clinic Bad Nauheim, Bad Nauheim, Germany -- Distler, O., Department of Rheumatology, University Hospital Zurich, Gloriastr. 25, 8091 Zürich, Switzerlanden_US
dc.identifier.volume29en_US
dc.identifier.issue2 SUPPL. 65en_US
dc.identifier.endpageS45en_US
dc.identifier.startpageS40en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record