| dc.description.abstract | Background and study aims : Abnormal expression of claudin-4 and ?-catenin play a role in carcinogenesis. The purpose of the present study was to examine claudin-4 and ?-catenin expression in normal and precancerous gastric mucosa. Patients and methods : Endoscopic biopsy specimens [normal gastric mucosa (n = 22), intestinal metaplasia (n = 24), dysplasia (n = 18), Helicobacter pylori (H. pylori)-associated chronic gastritis (n = 32) and remnant gastric mucosa (n = 18)] obtained from different 114 patients were examined by immunohistochemistry. Results : Claudin-4 expression was present in 94.4% of dysplasia, 87.5% of intestinal metaplasia, 62.5% H. pylori-associated chronic gastritis, and 88.9% remnant gastric mucosa but only 18.2% of normal gastric mucosa biopsies. Decreased expression of ?-catenin was present in 27.8% of dysplasia, 8.3% of intestinal metaplasia, 15.6% of H. pylori-associated chronic gastritis, and 22.2% of remnant gastric mucosa biopsies, but was not present in normal gastric mucosa. When compared with normal gastric mucosa, there was a significant difference in claudin-4 expression in all groups (P < 0.05), but a significant difference was detected in dysplasia and remnant gastric mucosa for ?-catenin (P < 0.05). Conclusions : Our results suggest that claudin-4 expression is upregulated in premalignant gastric alterations. | en_US |
| dc.contributor.department | Seckin, Y., Inonu University, Medical Faculty, Department of Gastroenterology, Malatya, Turkey -- Arici, S., Cumhuriyet University, Medical Faculty, Department of Pathology, Sivas, Turkey -- Harputluoglu, M., Inonu University, Medical Faculty, Department of Gastroenterology, Malatya, Turkey -- Yonem, O., Cumhuriyet University, Medical Faculty, Department of Gastroenterology, Sivas, Turkey -- Yilmaz, A., Cumhuriyet University, Medical Faculty, Department of Gastroenterology, Sivas, Turkey -- Ozer, H., Cumhuriyet University, Medical Faculty, Department of Pathology, Sivas, Turkey -- Karincaoglu, M., Inonu University, Medical Faculty, Department of Gastroenterology, Malatya, Turkey -- Demirel, U., Inonu University, Medical Faculty, Department of Gastroenterology, Malatya, Turkey | en_US |
