| dc.description.abstract | Aim: This study aimed to find salivary enzymes and/or cytokines that would reflect periodontitis, alone or in combination with salivary microbial markers. Material and Methods: The salivary concentrations of elastase, lactate dehydrogenase, interleukin-1? (IL-1?), interleukin-6, and tumour necrosis factor-?, and the presence of five periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola, were analysed from salivary specimens of 165 subjects, a subpopulation of Health 2000 Health Examination Survey in Finland; 84 of the subjects had probing pocket depth (PPD) of ?4 mm at 14 or more teeth (the advanced periodontitis group), while 81 subjects had no teeth with PPD of ?4 mm (the control group). All subjects had at least 20 teeth and no systemic diseases. Results: Among the salivary cytokines and enzymes tested, IL-1? was the only biomarker associated with periodontitis. An association was also found with the presence of multiple periodontal pathogens. Salivary IL-1? and the presence of multiple periodontal pathogens were associated with periodontitis at the same magnitude, when they were in the logistic regression model individually or together. Conclusion: We suggest that salivary IL-1? and the presence of multiple periodontal pathogens in saliva should be studied more thoroughly as markers of periodontitis. © 2009 John Wiley & Sons A/S. | en_US |
| dc.contributor.department | Gursoy, U.K., Department of Oral and Maxillofacial Surgery, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland, Department of Periodontology, Faculty of Dentistry, University of Cumhuriyet, Sivas, Turkey, Institute of Dentistry, Biomedicum University of Helsinki, PO Box 63, 00014 Helsinki, Finland -- Könönen, E., Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Helsinki, Finland, Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland -- Uitto, V.-J., Department of Oral and Maxillofacial Surgery, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland -- Pussinen, P.J., Department of Oral and Maxillofacial Surgery, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland -- Hyvärinen, K., Department of Oral and Maxillofacial Surgery, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland -- Suominen-Taipale, L., Unit of Living Conditions, Health and Wellbeing, Department of Environmental Health in Environmental Epidemiology Unit, National Institute for Health and Welfare (THL), Kuopio, Finland -- Knuuttila, M., Institute of Dentistry, University of Oulu, Oulu, Finland, Oral and Maxillofacial Department, Institute of Dentistry, Oulu University Hospital, Oulu, Finland | en_US |
