The relationship between oxidative stress, paraoxanase and injury severity in blunt trauma patients [Künt Travma Hastalari{dotless}nda Oksidatif Stres ve Paraoksanaz Düzeyleri ile Travma Şiddetinin Karşi{dotless}laşti{dotless}ri{dotless}lmasi{dotless}]
Özet
Aim: Shock index and Glascow coma scale(GCS) are the parameters used for the follow-up of trauma patient's prognosis. In case of trauma increased reactive oxygen species and oxidative stres induced increase in lipid peroxidation causes deterioration of the cell wall structure, and an increase of cell and tissue damage can be seen. We aimed to investigate the relationship between oxidative stress and paraoxonase, as an antioxidant, and prognosis of the trauma patients. Material and Method: Seventyone trauma patients who were admitted between July - September 2011 were included. Patients were classified according to GCS; Mild (61), moderate (6), and severe (3). Paraoxonase, oxidative stress index (OSI), total antioxidant capacity (TAC) and total oxidative stress (TOS) were compared with the shock index and the GCS. Results: We didn't found any difference between GCS groups and paraoxonase, TAS, TOS, OSI (p> 0.05). Also there wasn't any correlation between shock index and paraoxonase, TAC, TOS, OSI. Discussion: We make inferences that the admission levels of paraoxonase, TAC, TOS, OSI can't be used for determination of the trauma patients prognosis.
Kaynak
Journal of Clinical and Analytical MedicineCilt
4Sayı
3Koleksiyonlar
- Makale Koleksiyonu [5745]
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