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dc.contributor.authorOzdemir E.
dc.contributor.authorBagcivan I.
dc.contributor.authorGursoy S.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:32:36Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:32:36Z
dc.date.issued2013
dc.identifier.issn1512-8601
dc.identifier.urihttps://dx.doi.org/10.17305/bjbms.2013.2394
dc.identifier.urihttps://hdl.handle.net/20.500.12418/5585
dc.descriptionAssociation of Basic Medical Sciences of FBIHen_US
dc.description.abstractWhile opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood. The purpose of this study was to investigate effects of D1/D2 dopamine receptors antagonist perphenazine on morphine analgesia and tolerance in rats. Male Wistar albino rats weighing 190-205 g were used in these experiments. To constitute of morphine tolerance, animals received morphine (50 mg/kg) once daily for 3 days. After last dose of morphine was injected on day 4, morphine tolerance was evaluated by the analgesia tests. The analgesic effects of perphenazine (1, 5, and 10 mg/kg), Di-dopamine receptor antagonist SCH 23390 (1 mg/kg), D2-dopamine receptor antagonist eticlopride (1 mg/kg), and morphine were considered at 30-min intervals (o, 30, 60, 90, and 120 min) by tail-flick and hot-plate analgesia tests. Obtained data suggested that D1/D2 dopamine receptors antagonist perphenazine was capable of suppressing opioid tolerance, possibly by the mechanism of inhibiting D2-dopamine receptor. Because the data indicated that D2-dopamine receptor antagonist eticloride, but not D1-dopamine receptor antagonist SCH 23390, significantly decreased morphine tolerance in analgesia tests. In addition, administration of perphenazine with morphine increased morphine analgesia. Results from the present study suggested that dopamine receptors play a significant role in the morphine analgesic tolerance. In particular, D2-dopamine receptor has an important role rather than D1-dopamine receptor in development tolerance to morphine. © 2013 Association of Basic Medical Sciences of FB&H.en_US
dc.description.sponsorshipOzdemir, E.; Department of Physiology, School of Medicine, Cumhuriyet University, Yenişehir st, 58140 Sivas, Turkey; email: ercan_ozdemir@hotmail.comen_US
dc.language.isoengen_US
dc.relation.isversionof10.17305/bjbms.2013.2394en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnalgesiaen_US
dc.subjectDopamine receptorsen_US
dc.subjectMorphine toleranceen_US
dc.subjectPerphenazineen_US
dc.titleRole of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in ratsen_US
dc.typearticleen_US
dc.relation.journalBosnian Journal of Basic Medical Sciencesen_US
dc.contributor.departmentOzdemir, E., Department of Physiology, School of Medicine, Cumhuriyet University, Yenişehir st, 58140 Sivas, Turkey -- Bagcivan, I., Department of Pharmacology, School of Medicine, Cumhuriyet University, Yenişehir st, 58140 Sivas, Turkey -- Gursoy, S., Department of Anesthesiology and Reanimation, School of Medicine, Cumhuriyet University, Yenişehir st, 58140 Sivas, Turkeyen_US
dc.identifier.volume13en_US
dc.identifier.issue2en_US
dc.identifier.endpage125en_US
dc.identifier.startpage119en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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