| dc.description.abstract | This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells. © 2019 | en_US |
| dc.contributor.department | Hepokur, C., Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Biochemistry, Sivas, Turkey -- Kariper, İ.A., Erciyes University, Faculty of Education, Kayseri, Turkey -- Mısır, S., Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Biochemistry, Sivas, Turkey -- Ay, E., Istanbul University, Aziz Sancar Experimental Medicine Research Institute, Department of Molecular Medicine, İstanbul, Turkey, İstinye University, Vocational School of Health Services, İstanbul, Turkey -- Tunoğlu, S., Istanbul University, Aziz Sancar Experimental Medicine Research Institute, Department of Molecular Medicine, İstanbul, Turkey -- Ersez, M.S., Istanbul University, Aziz Sancar Experimental Medicine Research Institute, Department of Molecular Medicine, İstanbul, Turkey -- Zeybek, Ü., Istanbul University, Aziz Sancar Experimental Medicine Research Institute, Department of Molecular Medicine, İstanbul, Turkey -- Kuruca, S.E., Istanbul University, Faculty of Medicine, Department of Physiology, İstanbul, Turkey -- Yaylım, İ., Istanbul University, Aziz Sancar Experimental Medicine Research Institute, Department of Molecular Medicine, İstanbul, Turkey | en_US |
