| dc.description.abstract | This work describes a new, fast and sensitive method for the simultaneous determination of seven paraben residues including methyl paraben (MPB), ethyl paraben (EPB), propyl paraben (PPB), isopropyl paraben (iPPB), butyl paraben (BPB), isobutyl paraben (iBPB) and benzyl paraben (BzPB) in human whole blood, plasma and urine. The analytes were extracted from the biological matrices by an innovative technique, fabric phase sorptive extraction (FPSE) and subsequently analyzed by high-performance liquid chromatography (HPLC) coupled with photo diode array detector (PDA). The separation was carried out with a Spherisorb C18 column using methanol and phosphate buffer as mobile phases. Ketoprofen was used as the internal standard (IS). The analytical method has been validated according to the International Guidelines in terms of calibration curves for each biological matrix, precision (intra and inter day), trueness, selectivity, LODs, LOQs and ruggedness. Subsequently, the performance of the analytical method was evaluated on real biological samples. The proposed innovative method allows simultaneous analysis of seven paraben residues in three different biological matrices, including whole blood, plasma and urine and therefore it is easily applicable to monitor these substances in different biological samples. Furthermore, extraction technique used in this work is fast, easy to use and in accordance with the modern green analytical chemistry (GAC) principles. © 2019 Elsevier B.V. | en_US |
| dc.contributor.department | Tartaglia, A., Department of Pharmacy, University of Chieti–Pescara “G. d'Annunzio”, Via dei Vestini 31, Chieti, 66100, Italy -- Kabir, A., Department of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, 11200 SW 8th St, Miami, FL 33199, United States -- Ulusoy, S., Department of Chemistry, Faculty of Science, Cumhuriyet University, Sivas, 58140, Turkey -- Sperandio, E., Department of Pharmacy, University of Chieti–Pescara “G. d'Annunzio”, Via dei Vestini 31, Chieti, 66100, Italy -- Piccolantonio, S., Department of Pharmacy, University of Chieti–Pescara “G. d'Annunzio”, Via dei Vestini 31, Chieti, 66100, Italy -- Ulusoy, H.I., Department of Chemistry, Faculty of Science, Cumhuriyet University, Sivas, 58140, Turkey -- Furton, K.G., Department of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, 11200 SW 8th St, Miami, FL 33199, United States -- Locatelli, M., Department of Pharmacy, University of Chieti–Pescara “G. d'Annunzio”, Via dei Vestini 31, Chieti, 66100, Italy | en_US |
