Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, and anticancer activity
dc.contributor.author | Şahin-Bölükbaşı S. | |
dc.contributor.author | Şahin N. | |
dc.contributor.author | Tahir M.N. | |
dc.contributor.author | Arıcı C. | |
dc.contributor.author | Çevik E. | |
dc.contributor.author | Gürbüz N. | |
dc.contributor.author | Özdemir İ. | |
dc.contributor.author | Cummings B.S. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:32:52Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:32:52Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0020-1693 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.ica.2018.11.044 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/5642 | |
dc.description.abstract | In this study, we synthesized four novel unsymmetrically substituted NHC ligands (1a-d) and their Ag(I) complexes (2a-d). All new compounds were characterized using elemental analysis, FT-IR, 1H NMR, and 13C NMR spectroscopy and X-ray crystallography. The molecular structure of complex 2d was elucidated through single crystal X-ray diffraction analyses. Single crystal structural studies for complex 2d show that the benzene rings (C9–C14) and the central benzimidazole ring system make dihedral angles of 85.65(11)°. The Ag–Cl and Ag–C single bond lengths are 2.3553(7) and 2.096(2) Å respectively. The C–Ag–Cl bond angle is 168.27(7)°. Both salts and complexes were tested for their anti-cancer potential against three human cancer cell lines (DU-145, MCF-7, and MDA-MB-231) and non-cancer cells adipose from mouse (L-929) for 24 h, 48 h and 72 h using the MTT assays. However, the Ag(I)–NHC complexes (2a-d) showed a dose and time-dependent cytotoxic activity against all cell lines. MDA-MB-231 human breast carcinoma cells were the most sensitive to the Ag(I)–NHC complex displaying IC50 lower than 1 ?M all time points. Further, the IC50s for Ag(I)–NHC were higher in non-cancer cells, suggesting that complexes possessed noteworthy selectivity for human cancer cells. © 2018 Elsevier B.V. | en_US |
dc.description.sponsorship | National Institute of Biomedical Imaging and Bioengineering: EB0160100 National Institutes of Health U.S. Department of Defense: PC150431 GRANT11996600 | en_US |
dc.description.sponsorship | The authors thank the Scientific and Technological Research of Turkey (TÜBITAK-BIDEB), the National Research Fellow-ship Programme for grants to N. Ş. This project was supported in part with funds from the National Institutes of Health (NIH); National Institute of Biomedical Imaging and Bioengineering NIBIB (EB0160100 to B.S.C.) and a Department of Defense Prostate Cancer Research Program Idea Development Award (PC150431 GRANT11996600) to B.S.C. Appendix A | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier S.A. | en_US |
dc.relation.isversionof | 10.1016/j.ica.2018.11.044 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anticancer activity | en_US |
dc.subject | Benzimidazole-2-ylidene | en_US |
dc.subject | N-heterocyclic carbene | en_US |
dc.subject | Silver complex | en_US |
dc.title | Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, and anticancer activity | en_US |
dc.type | article | en_US |
dc.relation.journal | Inorganica Chimica Acta | en_US |
dc.contributor.department | Şahin-Bölükbaşı, S., Department of Biochemistry, Faculty of Pharmacy, University of Cumhuriyet, Sivas, 58140, Turkey, Dept. of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, Greece -- Şahin, N., Department of Basic Education, Faculty of Education, University of Cumhuriyet, Sivas, 58140, Turkey, Department of Chemistry, Faculty of Science and Art, University of İnönü, Malatya, 44280, Turkey, Catalysis Research and Application Center, University of İnönü, Malatya, 44280, Turkey -- Tahir, M.N., Department of Physics, University of Sargodha, Sargodha, Pakistan -- Arıcı, C., The Scientific And Technological Research Council of Turkey, Ankara, 06100, Turkey -- Çevik, E., Department of Biochemistry, Faculty of Pharmacy, University of Cumhuriyet, Sivas, 58140, Turkey -- Gürbüz, N., Department of Chemistry, Faculty of Science and Art, University of İnönü, Malatya, 44280, Turkey, Catalysis Research and Application Center, University of İnönü, Malatya, 44280, Turkey -- Özdemir, İ., Department of Chemistry, Faculty of Science and Art, University of İnönü, Malatya, 44280, Turkey, Catalysis Research and Application Center, University of İnönü, Malatya, 44280, Turkey -- Cummings, B.S., Dept. of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, Greece, Interdisciplinary Toxicology Program, University of Georgia, Athens, GA, Greece | en_US |
dc.identifier.volume | 486 | en_US |
dc.identifier.endpage | 718 | en_US |
dc.identifier.startpage | 711 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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