dc.contributor.author | Karakus G. | |
dc.contributor.author | Akin Polat Z. | |
dc.contributor.author | Karahan M. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:32:58Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:32:58Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0861-9808 | |
dc.identifier.uri | https://dx.doi.org/10.34049/bcc.51.2.5053 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/5664 | |
dc.description.abstract | In recent years, polymeric systems are selected as biomaterials because of their desired biocompatible properties and easy design/preparation of a number of different structures with lower toxicity and good solubility. Nontoxic polymeric drug carrier, maleic anhydride-co-vinyl acetate copolymer (MAVA), was prepared via free-radical chain polymerization at 80±0.1 °C. MEK (methyl ethyl ketone) and BPO (benzoyl peroxide) were used as the organic medium and radical initiator, respectively. Copolymer was conjugated with a broad-spectrum antimicrobial agent, miltefosine (MF, an oral drug in the treatment of leishmaniosis), Impavido® and Miltex®, 1:1 molar ratio of copolymer: drug for 48 h at 60 °C in aqueous medium in presence of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDAC). Fourier transform infrared (FTIR) and nuclear magnetic resonance (1H- and 31P-NMR) were used to characterize the structure of the copolymer and MAVA/MF conjugate. Molecular weights were measured via size-exclusion chromatography (SEC). Results, obtained from the spectroscopic and SEC analysis, verified that conjugation was successfully carried out with good water-solubility. WST-1 cytotoxicity tests, 24 h by quantitative analysis, were carried out for copolymer, miltefosine, and MAVA/MF. The cytotoxicity values, by comparing with control group, were found statistically significantly different (P<0.05). MAVA/MF copolymer/drug couple was successfully designed with lower cytotoxicity than the free drug (MF). © 2019 Bulgarian Academy of Sciences, Union of Chemists in Bulgaria. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bulgarian Academy of Sciences | en_US |
dc.relation.isversionof | 10.34049/bcc.51.2.5053 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 1H-NMR | en_US |
dc.subject | 31P-NMR | en_US |
dc.subject | Cytotoxic activity | en_US |
dc.subject | FTIR | en_US |
dc.subject | Maleic anhydride-co-vinyl acetate copolymer conjugation | en_US |
dc.subject | Miltefosine | en_US |
dc.subject | SEC | en_US |
dc.title | Design, synthesis, structural characterization and cell cytotoxicity of a new derivative poly(maleic anhydride-co-vinyl acetate)/miltefosine polymer/drug conjugate | en_US |
dc.type | article | en_US |
dc.relation.journal | Bulgarian Chemical Communications | en_US |
dc.contributor.department | Karakus, G., Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey -- Akin Polat, Z., Division of Medical Parasitology, School of Medicine, Cumhuriyet University, Sivas, Turkey -- Karahan, M., Division of Bioengineering, Faculty of Engineering and Natural Sciences, Üsküdar University, Uskudar-Istanbul, Turkey | en_US |
dc.identifier.volume | 51 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 278 | en_US |
dc.identifier.startpage | 267 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |