Matrix metalloproteinases and oxidative stress in patients with AECOPD [Akut Alevlenmeli Koah Hastalarında Matriks Metalloproteinazlar ve Oksidatif Stres]

Abstract

Aim: The aim of this study was to determine the relationship between oxidative status,matrix metalloproteinase-9 (MMP-9),matrix metalloproteinase-2 (MMP-2) and tissue metallopeptidase inhibitor-1 (TIMP-1) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). Material and Method: The study included a total of 35 patients with acute exacerbated COPD and 35 healthy nonsmoker controls. We assessed the concentrations of MMP-2,MMP-9,TIMP-1,total antioxidant status (TAS),and total oxidant status (TOS) in the study population. Results: MMP-9 concentrations were found as 201.19±12.91 pg/mL and 189.32±13.01 pg/mL in patients and controls,respectively. TAS concentrations were found as 20.27± 2.99 ?mol trolox equiv/l and 17.69±2.96 ?mol trolox equiv/l in patients and controls,respectively. Significant differences were found between patients and controls in terms of MM9 and TAS (< .001) concentrations. We also found lower TIMP-1 concentrations in patients (p=.035) than controls. We also found correlation between MMP-9,TAS (r=0.484,p<.001) and the oxidative status index (r= 0.221,p<.001). However,we did not find any significant correlation between MMP-2,TIMP-1,and oxidative stress markers (TAS and TOS). Discussion: It is thought that the antioxidant treatment approaches could be beneficial for AECOPD patients for preventing the MMP-9 related inflammation. © 2017,Journal of Clinical and Analytical Medicine. All rights reserved.