dc.contributor.author | Engin, Aynur | |
dc.contributor.author | Aydin, Huseyin | |
dc.contributor.author | Cinar, Ziynet | |
dc.contributor.author | Buyuktuna, Seyit Ali | |
dc.contributor.author | Bakir, Mehmet | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:37:00Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:37:00Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0146-6615 | |
dc.identifier.issn | 1096-9071 | |
dc.identifier.uri | https://dx.doi.org/10.1002/jmv.25467 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/5855 | |
dc.description | WOS: 000473215200004 | en_US |
dc.description | PubMed ID: 30905066 | en_US |
dc.description.abstract | Crimean-Congo hemorrhagic fever (CCHF) is a tick-mediated viral infection. Patients with CCHF may show various clinical presentations. The cause of this difference in the clinical course is not completely understood. Apoptosis is programmed cell death and plays an important role in regulating the immune system. Our knowledge of the role of apoptosis in CCHF disease is limited. We investigated the role of apoptosis and their relationship with the severity of the disease in CCHF. Thus, in 30 patients with CCHF and 30 healthy individuals, we analyzed the serum levels of cytochrome C, apoptotic protease activating factor-1 (Apaf 1), caspase 3, caspase 8, caspase 9, sFas, sFasL, perforin, granzyme B, and CK18 by enzyme-linked immunosorbent assay. This is the first study that research the serum levels of the mentioned apoptosis markers in adult patients with CCHF. We found that the serum levels of sFasL, cytochrome C, Apaf 1, caspase 3, caspase 8, caspase 9, perforin, granzyme B, and M30 were statistically significantly different in the acute phase of the disease compared with healthy individuals and patients in convalescent period. There was no association between the clinical severity of the disease and apoptosis markers. In conclusion, the results of our study suggested that the extrinsic and intrinsic apoptosis pathway play an important role in CCHF. | en_US |
dc.description.sponsorship | Cumhuriyet Universitesi [T-704]; Scientific Research Projects program of Cumhuriyet University | en_US |
dc.description.sponsorship | Cumhuriyet Universitesi, Grant/Award Number: Project no: T-704; Scientific Research Projects program of Cumhuriyet University | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1002/jmv.25467 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | apoptosis | en_US |
dc.subject | caspase | en_US |
dc.subject | Crimean-Congo hemorrhagic fever | en_US |
dc.subject | cytochrome C | en_US |
dc.subject | cytotoxic T lymphocyte | en_US |
dc.subject | soluble FasL | en_US |
dc.title | Apoptosis and its relation with clinical course in patients with Crimean-Congo hemorrhagic fever | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF MEDICAL VIROLOGY | en_US |
dc.contributor.department | [Engin, Aynur -- Buyuktuna, Seyit Ali -- Bakir, Mehmet] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-58140 Sivas, Turkey -- [Aydin, Huseyin] Cumhuriyet Univ, Dept Biochem, Sch Med, Sivas, Turkey -- [Cinar, Ziynet] Cumhuriyet Univ, Dept Biostat, Sch Med, Sivas, Turkey | en_US |
dc.contributor.authorID | Bakir, Mehmet -- 0000-0003-3702-1932 | en_US |
dc.identifier.volume | 91 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.endpage | 1393 | en_US |
dc.identifier.startpage | 1385 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |