Significant association between MDM2 T309G polymorphism and colorectal cancer

Abstract

Purpose: The Murine double minute 2 (MDM2) gene plays a crucial role in regulating and suppressing the function of apoptotic pathway. We investigated the relationship between MDM2 gene SNP309 (T309G) (rs2279744) polymorphism and colorectal cancer (CRC) in a Turkish population. Methods: The polymorphism T309G (rs2279744) in the MDM2 gene was studied in patients with colorectal cancer (n=135) and healthy control subjects (n=145) using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method The findings were evaluated using logistic regression and x(2) tests. Results: When CRC cases and controls were evaluated based on different habits and family cancer histories, a statistically significant relationship was found between CRC and alcohol consumption (x(2) =4.07, p=0.044). Cancer cases and controls had statistically significant different family histories of cancer (x(2) =6.82, p =0.009). There was also significant difference in TG genotype distribution in the MDM2 T309G polymorphism between those with and without cancer (OR=1.98, 95% CI =1.98-3.91, x(2) =4.00, p =0.045). Conclusions: The SNP309 polymorphism of the MDM2 gene is associated with increased CRC risk in the Turkish population.