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Synthesis and biological evaluation of novel indenopyrazole derivatives

dc.contributor.authorGezegen, Hayreddin
dc.contributor.authorTutar, Ugur
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorCeylan, Mustafa
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:37:05Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:37:05Z
dc.date.issued2019
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.22285
dc.identifier.urihttps://hdl.handle.net/20.500.12418/5913
dc.descriptionWOS: 000467327900013en_US
dc.descriptionPubMed ID: 30672630en_US
dc.description.abstractA series of novel indenopyrazole derivatives 2a-j and 3a-j were synthesized from the reaction of 1-(4-(hydroxy(1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl)-3-phenylurea derivatives 1a-j with hydrazine and phenylhydrazine, respectively. The obtained novel indenopyrazoles (2a-j and 3a-j) were evaluated for anticancer activity against HeLa and C6 cell lines. Antiproliferative activity was determined by the BrdU proliferation ELISA assay; 2a, 2b, 2d, 2h, and 3h were found to be the most active compounds. The compounds were also screened for antimicrobial activity, and all compounds showed moderate activity against used microorganisms.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [114Z634]; Scientific and Technological Research Council of Turkeyen_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 114Z634; The Scientific and Technological Research Council of Turkeyen_US
dc.language.isoengen_US
dc.publisherWILEYen_US
dc.relation.isversionof10.1002/jbt.22285en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-Benzoylindan-1-oneen_US
dc.subjectanticanceren_US
dc.subjectantimicrobialen_US
dc.subjectapoptosisen_US
dc.subjectindenopyrazoleen_US
dc.titleSynthesis and biological evaluation of novel indenopyrazole derivativesen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGYen_US
dc.contributor.department[Gezegen, Hayreddin -- Tutar, Ugur] Cumhuriyet Univ, Dept Nutr & Dietet, Fac Hlth Sci, Sivas, Turkey -- [Hepokur, Ceylan] Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkey -- [Ceylan, Mustafa] Gaziosmanpasa Univ, Fac Arts & Sci, Dept Chem, Tokat, Turkeyen_US
dc.contributor.authorIDCeylan, Mustafa -- 0000-0002-9184-4385en_US
dc.identifier.volume33en_US
dc.identifier.issue5en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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