Values of GLUT-1, COX-2, MMP-19 and p53 in the Differential Diagnosis of Squamous Cell Carcinoma and Keratoacanthoma

Abstract

Objective: The aim of this study is to investigate whether the expression of GLUT-1, COX2, MMP-19, p53 and Elastic-van Gieson (EVG) protein are significant in the differential diagnosis of squamous cell carcinoma (SCC) and keratoacanthoma (KA). Methods: A total of 156 cases, 105 of whom were SCC and 51 were KA, which were diagnosed between 2001 and 2011 years in Cumhuriyet University Department of Pathology, were examined histochemically by EVG and immunohistochemically by GLUT-1, COX-2, MMP-19 and p53. Results: Expression values of GLUT-1, COX-2, MMP-19, p53, and EVG were found to be statistically significant in the differential diagnosis of SCC and KA (p<0.05). The highest staining was seen with GLUT-1 (54%) and minimal staining with COX-2 (9%) among the tumor groups. The SCC and KA cases in the study were 60% and 41% immunoreactive with GLUT-1; 13% and 2% immunoreactive with COX-2; 24% and 0% immunoreactive with MMP-19; 31% and 16% immunoreactive with p53; 20% and 56.9% historeactive with EVG, respectively. Conclusion: All markers used in our study were found to be useful in the differential diagnosis of SCC and KA, but, we think that further molecular and genetic studies will facilitate the correct diagnosis.