dc.contributor.author | Tartaglia, Angela | |
dc.contributor.author | Locatelli, Marcello | |
dc.contributor.author | Kabir, Abuzar | |
dc.contributor.author | Furton, Kenneth G. | |
dc.contributor.author | Macerola, Daniela | |
dc.contributor.author | Sperandio, Elena | |
dc.contributor.author | Piccolantonio, Silvia | |
dc.contributor.author | Ulusoy, Halil I. | |
dc.contributor.author | Maroni, Fabio | |
dc.contributor.author | Bruni, Pantaleone | |
dc.contributor.author | Croce, Fausto | |
dc.contributor.author | Samanidou, Victoria F. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:37:13Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:37:13Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://dx.doi.org/10.3390/molecules24030382 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/5984 | |
dc.description | WOS: 000458934000006 | en_US |
dc.description | PubMed ID: 30678177 | en_US |
dc.description.abstract | This paper reports the performance comparison between the exhaustive and equilibrium extraction using classical Avantor C18 solid phase extraction (SPE) sorbent, hydrophilic-lipophilic balance (HLB) SPE sorbent, Sep-Pak C18 SPE sorbent, novel sol-gel Carbowax 20M (sol-gel CW 20M) SPE sorbent, and sol-gel CW 20M coated fabric phase sorptive extraction (FPSE) media for the simultaneous extraction and analysis of three inflammatory bowel disease (IBD) drugs that possess logP values (polarity) ranging from 1.66 for cortisone, 2.30 for ciprofloxacin, and 2.92 for sulfasalazine. Both the commercial SPE phases and in-house synthesized sol-gel CW 20M SPE phases were loaded in SPE cartridges and the extractions were carried out under an exhaustive extraction mode. FPSE was carried out under an equilibrium extraction mode. The drug compounds were resolved using a Luna C18 column (250 mm x 4.6 mm; 5 mu m particle size) in gradient elution mode within 20 min and the method was validated in compliance with international guidelines for the bioanalytical method validation. Novel in-house synthesized and loaded sol-gel CW 20M SPE sorbent cartridges were characterized in terms of their extraction capability, breakthrough volume, retention volume, hold-up volume, number of the theoretical plate, and the retention factor. | en_US |
dc.description.sponsorship | MIUR, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy | en_US |
dc.description.sponsorship | This research was funded by grant MIUR ex 60%, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.relation.isversionof | 10.3390/molecules24030382 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | FPSE | en_US |
dc.subject | in-house loaded SPE | en_US |
dc.subject | HPLC-PDA | en_US |
dc.subject | method validation | en_US |
dc.subject | IBD | en_US |
dc.subject | extraction | en_US |
dc.title | Comparison between Exhaustive and Equilibrium Extraction Using Different SPE Sorbents and Sol-Gel Carbowax 20M Coated FPSE Media | en_US |
dc.type | article | en_US |
dc.relation.journal | MOLECULES | en_US |
dc.contributor.department | [Tartaglia, Angela -- Locatelli, Marcello -- Macerola, Daniela -- Sperandio, Elena -- Piccolantonio, Silvia -- Maroni, Fabio -- Bruni, Pantaleone -- Croce, Fausto] Univ Chieti Pescara G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy -- [Kabir, Abuzar -- Furton, Kenneth G.] Florida Int Univ, Int Forens Res Inst, Dept Chem & Biochem, 11200 SW 8th St, Miami, FL 33199 USA -- [Ulusoy, Halil I.] Cumhuriyet Univ, Fac Pharm, Dept Analyt Chem, TR-58140 Sivas, Turkey -- [Samanidou, Victoria F.] Aristotle Univ Thessaloniki, Dept Chem, Lab Analyt Chem, Thessaloniki 54124, Greece | en_US |
dc.contributor.authorID | Maroni, Fabio -- 0000-0002-2534-5668; Maroni, Fabio -- 0000-0002-2534-5668; Bruni, Pantaleone -- 0000-0003-3728-0133; Ulusoy, Halil Ibrahim -- 0000-0002-8742-5145; Kabir, Abuzar -- 0000-0002-3740-8857; Croce, Fausto -- 0000-0001-9562-2694 | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 3 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |