Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis
dc.contributor.author | Bozkurt, Huseyin | |
dc.contributor.author | Bektasoglu, Pinar Kuru | |
dc.contributor.author | Borekci, Ali | |
dc.contributor.author | Ozturk, Ozden Caglar | |
dc.contributor.author | Kertmen, Hayri | |
dc.contributor.author | Egilmez, Reyhan | |
dc.contributor.author | Yuce, Mehmet Fatih | |
dc.contributor.author | Gurer, Bora | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:37:14Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:37:14Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1878-8750 | |
dc.identifier.issn | 1878-8769 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.wneu.2018.10.187 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/5987 | |
dc.description | WOS: 000457328100119 | en_US |
dc.description | PubMed ID: 30399469 | en_US |
dc.description.abstract | BACKGROUND: Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine if topical application of boric acid could be helpful in the prevention of epidural fibrosis. METHODS: Rats were randomly assigned to 2 control and 2 experimental groups (n = 8 for each group). The negative control group received no surgery, and the positive control group underwent laminectomy only. Experimental groups were classified according to the study agents applied onto the dura mater after laminectomy at the L3 level: 2.5% boric acid solution and 5% boric acid solution. The extent of epidural fibrosis was assessed 4 weeks later macroscopically and histopathologically. RESULTS: Boric acid reduced epidural fibrosis in rats after laminectomy. The effect of 5% boric acid solution was more pronounced (P < 0.05) compared with the 2.5% solution. CONCLUSIONS: The antifibrotic effect of boric acid solution for the prevention of epidural fibrosis suggests that boric acid should be further evaluated in future studies for the prevention of epidural fibrosis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.relation.isversionof | 10.1016/j.wneu.2018.10.187 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Boric acid | en_US |
dc.subject | Epidural fibrosis | en_US |
dc.subject | Laminectomy | en_US |
dc.title | Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis | en_US |
dc.type | article | en_US |
dc.relation.journal | WORLD NEUROSURGERY | en_US |
dc.contributor.department | [Bozkurt, Huseyin] Sivas Cumhuriyet Univ, Sch Med, Dept Neurosurg, Sivas, Turkey -- [Egilmez, Reyhan] Sivas Cumhuriyet Univ, Sch Med, Dept Pathol, Sivas, Turkey -- [Bektasoglu, Pinar Kuru -- Ozturk, Ozden Caglar -- Gurer, Bora] Univ Hlth Sci, Turkish Minist Hlth, Fatih Sultan Mehmet Educ & Res Hosp, Dept Neurosurg, Istanbul, Turkey -- [Yuce, Mehmet Fatih] Univ Hlth Sci, Fatih Sultan Mehmet Educ & Res Hosp, Turkish Minist Hlth, Dept Anesthesia, Istanbul, Turkey -- [Bektasoglu, Pinar Kuru] Marmara Univ, Sch Med, Dept Physiol, Istanbul, Turkey -- [Borekci, Ali] Sancaktepe Sehit Prof Dr Ilhan Varank Educ & Res, Dept Neurosurg, Turkish Minist Hlth, Istanbul, Turkey -- [Kertmen, Hayri] Univ Hlth Sci, Diskapi Educ & Res Hosp, Turkish Minist Hlth, Dept Neurosurg, Ankara, Turkey | en_US |
dc.contributor.authorID | Kuru Bektasoglu, Pinar -- 0000-0001-9889-9955 | en_US |
dc.identifier.volume | 122 | en_US |
dc.identifier.endpage | E994 | en_US |
dc.identifier.startpage | E989 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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