dc.contributor.author | Kucukoflaz, Merve | |
dc.contributor.author | Kaya, Berna Saracoglu | |
dc.contributor.author | Caglayan, Mustafa Oguzhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:37:20Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:37:20Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2574-0881 | |
dc.identifier.issn | 2574-089X | |
dc.identifier.uri | https://dx.doi.org/10.1080/03602559.2018.1520252 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/6029 | |
dc.description | WOS: 000463821100006 | en_US |
dc.description.abstract | In this study, we synthesized poly (vinyl acetate-co-divinyl benzene) microspheres with various monomer/cross-linker contents for oral/topical sustained drug release applications and determined the micromechanical properties by nanoindentation. Compression elastic moduli of materials were calculated by using the limited depth of indentation according to Hertz elastic deformation model and presented as the histogram of multiple data. In terms of drug release practices, poly (VAc-co-DVB) microspheres with a high DVB content, especially in topical applications, are expected to carry drugs under mechanical stresses of less than 1.0 GPa. [GRAPHICS] . | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS INC | en_US |
dc.relation.isversionof | 10.1080/03602559.2018.1520252 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Controlled drug release | en_US |
dc.subject | drug delivery systems | en_US |
dc.subject | polymeric microsphere | en_US |
dc.subject | nanoindentation | en_US |
dc.subject | nanomechanical properties | en_US |
dc.title | Determination of mechanical properties of polymeric microspheres used in controlled drug delivery systems by nanoindentation | en_US |
dc.type | article | en_US |
dc.relation.journal | POLYMER-PLASTICS TECHNOLOGY AND MATERIALS | en_US |
dc.contributor.department | [Kucukoflaz, Merve -- Caglayan, Mustafa Oguzhan] Cumhuriyet Univ, Nanotechnol Dept, Sivas, Turkey -- [Kaya, Berna Saracoglu] Cumhuriyet Univ, Chem Engn Dept, Sivas, Turkey | en_US |
dc.contributor.authorID | SARACOGLU KAYA, Berna -- 0000-0003-4706-5146 | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.endpage | 775 | en_US |
dc.identifier.startpage | 765 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |