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dc.contributor.authorOz, Muhammed
dc.contributor.authorKarakus, Savas
dc.contributor.authorYildirim, Malik
dc.contributor.authorBagci, Binnur
dc.contributor.authorSari, Ismail
dc.contributor.authorBagci, Gokhan
dc.contributor.authorYildiz, Caglar
dc.contributor.authorAkkar, Ozlem
dc.contributor.authorCetin, Ali
dc.contributor.authorYanik, Ali
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:37:36Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:37:36Z
dc.date.issued2018
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.urihttps://dx.doi.org/10.4103/0973-1482.187291
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6128
dc.descriptionWOS: 000452548200021en_US
dc.descriptionPubMed ID: 30488844en_US
dc.description.abstractAim: Although several associations were found between Dicer rs3742330 single nucleotide polymorphism (SNP) and development and prognosis of some epithelial cancers, relationship between the SNP rs3742330 and endometrial cancer (EC) has not yet been studied. We aimed to investigate the prognostic role of rs3742330 SNP of Dicer gene in EC patients. Subjects and Methods: A total of 80 EC patients and 80 control subjects included in the study. Real-time polymerase chain reaction and the allele discrimination technique was used for genotyping of rs3742330 SNP. Results: There was no significant difference between EC patients and control subjects with regard to the genotype and allele frequencies for Dicer rs3742330 SNP (P > 0.05). Despite Dicer rs3742330 SNP had no prognostic value in terms of stage, grade, lymphovascular invasion, myometrial invasion, tumor size, and histopathology; malignant peritoneal cytology has been detected higher in the patients bearing AA genotype compare with AG genotype (P = 0.023). Higher recurrence rate and shorter time to recurrence were found in patients bearing AG and GG genotype compare with AA genotype (P = 0.009). Conclusion: Dicer rs3742330 AG and GG genotypes may have the potential to be used as a predictor of poor prognosis in the management of EC case.en_US
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University [T-620]en_US
dc.description.sponsorshipThis work is supported by the Scientific Research Project Fund of Cumhuriyet University under the project number "T-620."en_US
dc.language.isoengen_US
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONSen_US
dc.relation.isversionof10.4103/0973-1482.187291en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiceren_US
dc.subjectendometrial canceren_US
dc.subjectmicroRNAen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.titleGenetic variants in the microRNA machinery gene (Dicer) have a prognostic value in the management of endometrial canceren_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF CANCER RESEARCH AND THERAPEUTICSen_US
dc.contributor.department[Oz, Muhammed -- Karakus, Savas -- Yildiz, Caglar -- Akkar, Ozlem -- Cetin, Ali -- Yanik, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Yildirim, Malik -- Bagci, Gokhan] Cumhuriyet Univ, Sch Med, Dept Med Genet, Sivas, Turkey -- [Sari, Ismail] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth Sci, Dept Nutr & Dietet, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894; Sari, Ismail -- 0000-0003-3732-2102en_US
dc.identifier.volume14en_US
dc.identifier.issue6en_US
dc.identifier.endpage1284en_US
dc.identifier.startpage1279en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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